Cullin 1

a negative regulator of cell cycle; NM_001203732 (Arabidopsis)

Also Known As:

AUXIN RESISTANT 6 protein, Arabidopsis; AXR6 protein, Arabidopsis; CDC53 protein, human; CUL1 protein, Arabidopsis; CUL1 protein, human; Cul-1 protein; Cul-1 protein, C elegans; Cul1 protein, mouse; Cul1 protein, rat; Lin-19 protein; cul-1 protein, Drosophila; cul-1 protein, S cerevisiae; cullin 1 protein, mouse; cullin 1 protein, rat; cullin-1, human; hCUL1 protein, human; lin19 protein, Drosophila

Networked: 19 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gao, Daming: 2 articles (03/2011 - 09/2010)
2.	Gygi, Steven P: 2 articles (03/2011 - 09/2010)
3.	Inuzuka, Hiroyuki: 2 articles (03/2011 - 09/2010)
4.	Shaik, Shavali: 2 articles (03/2011 - 09/2010)
5.	Tseng, Alan: 2 articles (03/2011 - 09/2010)
6.	Wan, Lixin: 2 articles (03/2011 - 09/2010)
7.	Wei, Wenyi: 2 articles (03/2011 - 09/2010)
8.	Zhai, Bo: 2 articles (03/2011 - 09/2010)
9.	Chingtham, Santhalembi: 1 article (01/2022)
10.	Kulkarni, Diwakar D: 1 article (01/2022)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 12/15/2021 - "Among these compounds, compound 4g was identified as a novel neddylation inhibitor and decreased the neddylation levels of cullin 1, cullin 3 and cullin 5. Mechanistic studies demonstrated that compound 4g could inhibit the migration ability of gastric cancer cells and induce apoptosis partly mediated by the Nrf2-Keap1 pathway. " 04/11/2016 - "Here we showed that in gastric cancer cells, MLN4924 rapidly inhibited cullin 1 neddylation and remarkably suppressed growth and survival as well as migration in a dose-and time-dependent manner. " 01/13/2013 - "CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line." 01/01/2021 - "CDK-associated cullin 1 (CACUL1) has been shown to regulate colorectal carcinoma, lung cancer, and gastric cancer development. "
2.	Parkinson Disease (Parkinson's Disease) 11/20/2009 - "The aim of this study was to develop a new model of sporadic Parkinson disease (PD) based on silencing of the SKP1A gene, a component of the ubiquitin-proteasome/E3 ligase complex, Skp1, Cullin 1, F-box protein, which was found to be highly decreased in the substantia nigra of sporadic PD patients. " 03/01/2009 - "The list included multiple proteins involved in colon cancer pathogenesis: cathepsin B and cathepsin D, cullin 1, Parkinson disease 7, muscle pyruvate kinase, and Ran. "
3.	Lung Neoplasms (Lung Cancer) 07/19/2013 - "CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells." 07/19/2013 - "In this study, we investigated the expression of CDK-associated Cullin 1 (CAC1) in lung cancer, the effect of CAC1 on the proliferation of human lung cancer A549 cells, and the activation of signaling pathways of mitogen-activated protein kinases (MAPKs). " 01/01/2021 - "CDK-associated cullin 1 (CACUL1) has been shown to regulate colorectal carcinoma, lung cancer, and gastric cancer development. "
4.	Neoplasms (Cancer) 09/10/2010 - "These findings indicate that the Rictor/Cullin-1 E3 ligase activity is regulated by a specific signal relay cascade and that misregulation of this mechanism may contribute to the frequent overexpression of SGK1 in various human cancers." 11/01/2018 - "The FBXW7 tumor suppressor is part of a SCF (complex of SKP1, Cullin 1, F-box protein) ubiquitin ligase complex which controls the degradation of numerous substrates that, if not properly regulated, can contribute to the initiation or progression of tumorigenesis. " 11/15/2011 - "The expression of REST and of an S-phase kinase-associated protein 1/cullin 1/F-box (SCF) protein complex that contains the F-box protein β-transducin repeat-containing protein (β-TRCP) (SCF(β-TRCP) ) in neuroblastoma tumor samples and cell lines was analyzed by immunofluorescence and Western blot analysis. "
5.	Carcinogenesis 11/01/2018 - "The FBXW7 tumor suppressor is part of a SCF (complex of SKP1, Cullin 1, F-box protein) ubiquitin ligase complex which controls the degradation of numerous substrates that, if not properly regulated, can contribute to the initiation or progression of tumorigenesis. "

Related Drugs and Biologics

1.	F-Box Proteins
2.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
3.	Ubiquitin
4.	Proteasome Endopeptidase Complex (Proteasome)
5.	Cullin Proteins (Cullins)
6.	Mitogen-Activated Protein Kinases
7.	Proteins (Proteins, Gene)
8.	Cyclin G1
9.	Cyclin B1
10.	Connective Tissue Growth Factor