parbendazole

05/01/2022 - "Our study repositioned an anthelmintic parbendazole to treat HNSCC, which revealed a therapeutic utility and provided a new treatment option for human cancers."
05/01/2022 - "Parbendazole was further proved as an effective tubulin polymerization inhibitor, which can block the cell cycle, cause apoptosis and prevent cell migration, and it exhibited reasonable therapeutic effect and low toxicity in the in vivo and in vitro anti-tumor evaluation. "
08/01/2020 - "The present review summarizes central literature regarding the anticancer effects of benzimidazole anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, and flubendazole in cancer cell lines, animal tumor models, and clinical trials. "

08/05/2022 - "Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC."
05/01/2022 - "Herein, we performed a batch query in the connectivity map (cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and screened out parbendazole as a most promising compound, which had an excellent inhibitory effect on the proliferation of HNSCC cell lines. "
08/05/2022 - "Parbendazole was previously identified as a potential HNSCC therapy candidate in our research. "
05/01/2022 - "Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning."
05/01/2022 - "Our study repositioned an anthelmintic parbendazole to treat HNSCC, which revealed a therapeutic utility and provided a new treatment option for human cancers."

08/01/1974 - "Controlled tests of parbendazole and thiabendazole against natural infections of gastrointestinal helminths of lambs."
11/01/1989 - "Groups of 10 goats, harbouring both naturally acquired and experimental infections of gastrointestinal nematodes, were drenched with either levamisole (5 mg kg-1), albendazole (3.8 mg kg-1) or parbendazole (15 mg kg-1), or remained untreated. "
03/01/1979 - "A comparative sutdy of anthelmintic effect of naphthalophos and parbendazole against natural infection of gastro-intestinal worms of sheep."
10/01/1971 - "Comparative activity of pyrantel tartrate, parbendazole, and levamisole at two dose levels against naturally acquired helminth infections in sheep."
04/01/1971 - "Comparative activity of thiabendazole, levamisole, and parbendazole against natural infections of helminths in sheep."

03/01/1982 - "Parbendazole and albendazole were effective at daily oral dose levels of 1 mg/kg of body weight and at feeding dose levels of 10 mg/kg of feed, respectively. "
10/01/1995 - "Daily dosage levels of thiabendazole, parbendazole, oxibendazole, mebendazole, and albendazole, as high as 200, 30, 10, 15, and 15 mg/kg of body weight, respectively, were not efficacious in neonatal mice. "
03/01/1993 - "Activity against naturally acquired internal helminths was evaluated for cambendazole (CBZ: dosage, 20 mg/kg of body weight), fenbendazole (FBZ: 5 or 7.5 mg/kg), mebendazole (MBZ: 10 mg/kg); oxfendazole (OFZ: 3.5 or 10 mg/kg), oxibendazole (OBZ: 10 mg/kg); parbendazole (PBZ: 15 mg/kg), phenothiazine (PTZ: 550 mg/kg); pyrantel pamoate (PRT: 25 mg base/kg), tetramizole (TET: 15 mg/kg); thiabendazole (TBZ: 30 or 44 mg/kg), and trichlorfon (TCF: 100 mg/kg). "

07/01/1974 - "Letter: Parbendazole and congenital abnormalities."
09/01/1981 - "Out of a total of 68 lambs, born from ewes treated at various stages of gestation with parbendazole at 180 mg/kg, 5 showed the paralysis syndrome, 5 showed skeletal deformities, 2 were ataxic, while 1 foetus was aborted. "