antamanide

cyclic decapeptides otained from the green death cup toadstool (Amanita phalloides). Acts as an antidote against poisoning by phallotoxins by preventing accumulation & absorption of the toxin in the liver; minor descriptor (75-86); on-line & INDEX MEDICUS search PEPTIDES, CYCLIC (75-86)

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Faulstich, Heinz: 1 article (05/2006)
2.	Keller, Daniela: 1 article (05/2006)
3.	Keppler, Dietrich: 1 article (05/2006)
4.	Letschert, Katrin: 1 article (05/2006)

Related Diseases

1.	Edema (Dropsy) 03/01/1991 - "Antamanide treatment was as effective in limiting lung and heart edema, but, in contrast to phalloidin, antamanide prevented kidney edema and did not lead to an alteration in the liver W/D. " 03/01/1991 - "Attenuation of IL-2-induced multisystem organ edema by phalloidin and antamanide."
2.	Ischemia 10/01/1991 - "The aim of this study was to determine whether phalloidin (1 microM) or antamanide (1 microM), cyclic peptides that stabilize dense peripheral band and stress fiber F-actin in endothelium, would attenuate the increase in microvascular permeability induced by 4 h of ischemia and 30 min of reperfusion (I/R) in the isolated canine gracilis muscle. "
3.	Poisoning 05/01/2006 - "Accordingly, toxin uptake was inhibited by OATP1B3 substrates and inhibitors (cyclosporin A, rifampicin, the quinoline derivatives MK571 ([(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)((3-dimethylamino-3-oxopropyl)thio)methyl)thiopropanoic acid]) and montelukast, the cholecystokinin octapeptide (CCK-8), paclitaxel, and bromosulfophthalein), as well as by some antidotes used in the past for the treatment of human amatoxin poisoning (silibinin dihemisuccinate, penicillin G, prednisolone phosphate, and antamanide). "
4.	Paralysis (Palsy) 03/01/1983 - "Arrhenius paralysis yielded high apparent activation energies for the uptake of cholate, iodipamide, and antamanide being 89, 77 and 55 kJ/mol respectively but only 22 kJ/mol for bromosulfophthalein. "
5.	Neoplasms (Cancer) 02/01/1999 - "Phakellistatin 8 is a cyclic decapeptide that inhibits cancer cell growth and has sequence and structure similar to antamanide. "

Related Drugs and Biologics

1.	Phalloidine
2.	Cyclic Peptides
3.	Actins (F Actin)
4.	Sulfobromophthalein (Sulfobromophthalein Sodium)
5.	Cholates
6.	Paclitaxel (Taxol)
7.	Cyclosporine (Ciclosporin)
8.	Sincalide
9.	Rifampin (Rifampicin)
10.	Penicillin G (Benzylpenicillin)