diacetyldiphenylurea bisguanylhydrazone (DDUG)

antineoplastic agent particularly effective as an antileukemic agent; has been shown to be active against leukemia L1210 in mice; minor descriptor (75-86); on-line & INDEX MEDICUS search CARBANILIDES (75-86); RN given refers to parent cpd

Also Known As:

DDUG; 4,4'-diacetylcarbanilide 4,4'-bis(amidinohydrazone); 4,4'-diacetyldiphenylurea 4,4'-bis(guanylhydrazone); NSC 109555; NSC-109555; NSC109555; diacetyldiphenylurea bisguanylhydrazone, dihydrochloride

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bae, Insoo: 1 article (10/2013)
2.	Cho, Chi Heum: 1 article (10/2013)
3.	Duong, Hong-Quan: 1 article (10/2013)
4.	Hong, Young Bin: 1 article (10/2013)
5.	Kim, Jung Soon: 1 article (10/2013)
6.	Kim, Yeon Jeong: 1 article (10/2013)
7.	Lee, Hee-Seok: 1 article (10/2013)
8.	Seong, Yeon-Sun: 1 article (10/2013)
9.	Wang, Antai: 1 article (10/2013)
10.	Yi, Yong Weon: 1 article (10/2013)

Related Diseases

1.	Neoplasms (Cancer) 02/01/1976 - "4,4'-Diacetyldiphenylurea-bis(guanylhydrazone) (DDUG), an agent very effective against several animal leukemias and tumors, was found, spectrophotometrically, to interact in a biphasic manner with several natural, native and heat-denatured, and synthetic DNAs. "
2.	Leukemia 02/01/1976 - "4,4'-Diacetyldiphenylurea-bis(guanylhydrazone) (DDUG), an agent very effective against several animal leukemias and tumors, was found, spectrophotometrically, to interact in a biphasic manner with several natural, native and heat-denatured, and synthetic DNAs. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 10/01/2013 - "In this study, the combination treatment of NSC109555 plus GEM demonstrated strong synergistic antitumour effect in four pancreatic cancer cells (MIA PaCa-2, CFPAC-1, Panc-1 and BxPC-3). " 10/01/2013 - "Recently, we found that co-treatment of NSC109555 (a potent and selective CHK2 inhibitor) potentiated the cytotoxic effect of gemcitabine (GEM) in pancreatic cancer MIA PaCa-2 cells. "
4.	Ascites 01/30/1987 - "We also show that the in vivo antileukemic activity of DDUG in the L1210 ascites mouse model is antagonized by biologically active polyamines. "
5.	Adenocarcinoma 10/01/2013 - "Here, we further examined whether NSC109555 could enhance the antitumour effect of GEM in pancreatic adenocarcinoma cell lines. "

Related Drugs and Biologics

1.	Polyamines
2.	Gemcitabine