octotropine methylbromide (anisotropine methylbromide)

minor descriptor (65-86); on line & INDEX MEDICUS search TROPANES (69-86); RN given refers to endo-isomer

Also Known As:

anisotropine methylbromide; octatropine; Valpin; anisotropine methylbromide, (endo)-isomer

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Drug Context: Research Results

Organic Chemicals: 133
- Aza Compounds: 3
  - Azabicyclo Compounds
    - Tropanes: 1
      - octotropine methylbromide: 9
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Tropanes: 1
    - octotropine methylbromide: 9
- Bridged-Ring Heterocyclic Compounds
  - Tropanes: 1
    - octotropine methylbromide: 9
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - Tropanes: 1
        octotropine methylbromide: 9

Experts

1.	Attili, A: 1 article (03/2010)
2.	Ciacci, C: 1 article (03/2010)
3.	Iaquinto, G: 1 article (03/2010)
4.	Magni, E: 1 article (03/2010)
5.	Maurano, A: 1 article (03/2010)
6.	Pace, F: 1 article (03/2010)
7.	Porro, G Bianchi: 1 article (03/2010)
8.	Savarino, V: 1 article (03/2010)

Related Diseases

1.	Spasm (Spasms) 11/01/1966 - "Anisotropine methylbromide for relief of gastrointestinal spasm: double-blind crossover comparison study with belladonna alkaloids and phenobarbital." 12/22/1970 - "[Anisotropine methylbromide (Valpin) in the treatment of spasms of the gastrointestinal system. " 04/01/1972 - "Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs."
2.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 03/01/2010 - "Octatropine methyl bromide and diazepam combination (Valpinax) in patients with irritable bowel syndrome: a multicentre, randomized, placebo-controlled trial." 03/01/2010 - "To investigate the efficacy and tolerability of octatropine methyl bromide plus diazepam (Valpinax) in patients with irritable bowel syndrome (IBS). "
3.	Muscle Spasticity (Spastic) 05/01/1973 - "[Clinical study of the selectivity, tolerance and therapeutic status of anisotropine methylbromide and its combinations (Vapin Complex) in digestive pathology and in spastic changes of the biliary tract]." 09/30/1982 - "[Effectiveness of octatropine methylbromide (OMB) in the treatment of gastritis, duodenal ulcer and spastic colon--a double blind study]."
4.	Duodenal Ulcer (Curling's Ulcer) 09/30/1982 - "[Effectiveness of octatropine methylbromide (OMB) in the treatment of gastritis, duodenal ulcer and spastic colon--a double blind study]." 01/01/1989 - "Octatropine-methyl-bromide and sulglycotide salt in the short-term treatment of active duodenal ulcer. "
5.	Abdominal Pain (Pain, Abdominal) 03/01/2010 - "Patients with IBS and an abdominal pain and discomfort score of > or = 3, who may be considered in the active phase of the disease, may derive some benefits from octatropine plus diazepam. " 03/01/2010 - "A prespecified subgroup analysis was conducted in patients with an abdominal pain and discomfort score > or = 3. The primary efficacy endpoint showed a tendency towards a statistically significant benefit for octatropine plus diazepam over placebo among patients with a baseline abdominal pain and discomfort score of > or = 3 (3 vs. 0 patients; p = 0.059). "

Related Drugs and Biologics

1.	methyl bromide (bromomethane)
2.	Phenobarbital (Luminal)
3.	Diazepam (Valium)
4.	Belladonna Alkaloids
5.	valpinax
6.	octotropine methylbromide (anisotropine methylbromide)
7.	Parasympatholytics (Antispasmodics)
8.	Salts
9.	Dipyrone (Metamizole)
10.	Acetylcholine (Acetylcholine Chloride)