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deoxycytidylate hydroxymethyltransferase

minor descriptor (75-85); on-line & Index Medicus search TRANSFERASES (75-85); catalyzes the synthesis of 5-hydroxymethyldeoxycytidylate from deoxycytidylate plus 5,10-methylenetetrahydrofolate; occurs in some bacteriophage
Also Known As:
5,10-methylenetetrahydrofolate-deoxycytidylate 5-hydroxymethyltransferase; DCMP hydroxymethylase; DCMP hydroxymethyltransferase
Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1. Infections
03/01/1976 - "With these mutants the rate of increase of dTMP synthetase and dCMP hydroxymethylase activities was always substantially lower than after infection by wild-type phage. "
03/01/1976 - "T4-induced dCMP hydroxymethylase and dTMP synthetase, though demonstrable in extracts soon after infection, are not active in vivo until about 5 min. The in vivo activities increase exponentially for approximately 15 min and then become constant. "
10/01/1973 - "However, in the DNA(-) state (where S1 is missing), SP62 continues to make dCTPase (gene 56), dCMP hydroxymethylase (gene 42), and deoxynucleotide kinase (gene 1) for at least an hour; this results in production of up to 13 times the normal level of dCTPase at 60 min after infection, or 6 times the DNA(-) level. "
02/01/1976 - "The role of the T4 bacteriophage regA gene in stabilizing early mRNA was investigated by assaying the level of functional mRNA from eight prereplicative genes (56 [dCMP hydroxymethylase], cd [dCMP deaminase], 1 [deoxynucleotide kinase], rIIA, rIIB, 46 [DNA arrest], and 45) during extended infection of Escherichia coli B with T4 regA-, 43- and T4 43- bacteriophage. "
10/01/1969 - "Included are studies of DNA synthesis and phage production, and of the control of both early and late protein synthesis after infection of Escherichia coli B with various T4 mutants defective in genes 56 (dCTPase), 42 (dCMP hydroxymethylase), 1 (deoxynucleotide kinase), 43 (DNA polymerase), 30 (polynucleotide ligase), 46 and 47 (DNA breakdown) or e(lysozyme). "

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. (deoxy)nucleoside-phosphate kinase (deoxynucleotide kinase)
3. Ligases (Synthetase)
4. dCTP pyrophosphatase
5. Proteins (Proteins, Gene)
6. Polynucleotides
7. Muramidase (Lysozyme)
8. DNA-Directed DNA Polymerase (Polymerases, DNA)
9. Thymidine Monophosphate (TMP)
10. Messenger RNA (mRNA)