methasquin

folic acid antagonist that has been used in the treatment of experimental leukemia; acts by inhibiting the dihydrofolate reductase in the cell; minor descriptor (75-85); on-line & Index Medicus search ASPARTIC ACID/AA (75-85); RN given refers to parent cpd

Also Known As:

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Neuroblastoma 08/01/1986 - "A 6-day in vitro growth-inhibition assay was used to determine relative sensitivity of six human neuroblastoma cell lines to three classes of cancer chemotherapeutic agents: antimetabolites (methotrexate, methasquin, and cytarabine); antimitotics (vincristine, vinblastine, vindesine, colchicine, and demecolcine); and antibiotics (dactinomycin and doxorubicin). "
2.	Neoplasms (Cancer) 08/01/1986 - "A 6-day in vitro growth-inhibition assay was used to determine relative sensitivity of six human neuroblastoma cell lines to three classes of cancer chemotherapeutic agents: antimetabolites (methotrexate, methasquin, and cytarabine); antimitotics (vincristine, vinblastine, vindesine, colchicine, and demecolcine); and antibiotics (dactinomycin and doxorubicin). "
3.	Leukemia L1210 10/01/1972 - "Comparative studies on the transport of aminopterin, methotrexate, and methasquin by the L1210 leukemia cell."

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	Antimitotic Agents
3.	Vindesine (Vindesin)
4.	Vincristine (Oncovin)
5.	Vinblastine (Vinblastine Sulfate)
6.	Doxorubicin (Adriamycin)
7.	Demecolcine
8.	Dactinomycin (Actinomycin)
9.	Cytarabine (Cytosar-U)
10.	Colchicine