(all-E) phytoene

C40 carotenoid biosynthesized in bacteria; minor descriptor (75-84); EP to CAROTENOIDS (85); on-line & Index Medicus search CAROTENOIDS (75-85); RN given refers to (all-trans)-isomer; RN for cpd without isomeric designation

Also Known As:

Networked: 22 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Erdman, John W: 3 articles (09/2011 - 02/2006)
2.	Campbell, Jessica K: 2 articles (12/2007 - 02/2006)
3.	Lila, Mary Ann: 2 articles (12/2007 - 02/2006)
4.	Miyashita, K: 2 articles (12/2001 - 01/2001)
5.	Nagao, A: 2 articles (12/2001 - 01/2001)
6.	El-Ayouty, Yassin M: 1 article (10/2021)
7.	Fathey, Hoda A: 1 article (10/2021)
8.	Ismaiel, Mostafa M S: 1 article (10/2021)
9.	Carr, John P: 1 article (11/2020)
10.	Chen, Hui: 1 article (11/2020)

Related Diseases

1.	Neoplasms (Cancer) 02/08/2006 - "Introduction of 14C-sucrose to the tomato cell culture medium enabled the production of 14C-labeled phytoene for subsequent prostate tumor cell uptake studies. " 01/01/1997 - "In the present study, the cancer-preventive activity of phytoene was also confirmed biotechnologically when mammalian cells producing phytoene were resistant to H-ras-induced cell transformation. " 06/18/1998 - "Here, the cancer-preventive activity of phytoene was demonstrated using new a biotechnological method; i.e., establishment of mammalian cells producing phytoene was followed by the introduction of crtB gene which encodes phytoene synthase, and these cells were proven to acquire the resistance against transformation imposed by transfection of activated oncogenes. " 02/08/2006 - "In DU 145 prostate tumor cells, it was determined that 15-cis-phytoene and an oxidized product of phytoene were taken up and partially metabolized by the cells. " 01/01/1982 - "For tumors induced by UV-B alone, beta-carotene-phytoene- and canthaxanthin-treated mice developed fewer tumors per mouse, with a delay in tumor appearance, than did control mice. "
2.	Prostatic Neoplasms (Prostate Cancer) 02/08/2006 - "This work describes the development and utilization of a plant cell culture production approach to biosynthesize and radiolabel phytoene and phytofluene for prostate cancer cell culture studies. " 12/01/2007 - "The contribution of other tomato carotenoids, phytoene (PE) and phytofluene (PF), towards prostate cancer risk has not been adequately studied. " 12/01/2001 - "On the other hand, phytoene, canthaxanthin, beta-cryptoxanthin and zeaxanthin did not affect the growth of the prostate cancer cells. " 01/01/2019 - "Secondary linear regression analyses of data from a dose-escalation study of prostate cancer patients [n = 47; mean ± SEM age: 60 ± 1 y; BMI (in kg/m2): 32 ± 1] consuming 0, 1, or 2 cans of tomato-soy juice/d (163 mL/can; 20.6 mg lycopene 1.2 mg β-carotene/can) for 24 ± 0.7 d before prostatectomy were conducted to explore 11 SNP genotype effects on the change in plasma lycopene and plasma and prostate tissue concentrations of lycopene, β-carotene, phytoene, and phytofluene. "
3.	Inflammation (Inflammations) 05/01/2018 - "This double-blind, randomized, placebo-controlled crossover trial determined if ingestion of a supplement containing a tomato complex with lycopene, phytoene, and phytofluene (T-LPP) and other compounds for 4 weeks would attenuate inflammation, muscle damage, and oxidative stress postexercise and during recovery from a 2-hr running bout that included 30 min of -10% downhill running. " 08/01/2013 - "In this study, we investigated the effects of supplementing tomato extract (TE), which contains mainly lycopene (LY) and less amounts of its precursors, phytoene (PT) and phytofluene (PTF) against high-fat-diet related hepatic inflammation and lipid profiles, and carcinogenesis. "
4.	Carcinogenesis 01/01/2002 - "Antioxidative phytoene-containing animal foods may be classified as a novel type of functional food, which has the preventive activity against carcinogenesis, as well as the ability to reduce the accumulation of oxidative damages, which are hazardous for human health." 01/01/2002 - "In fact, establishment of mammalian cells producing phytoene was succeeded by the introduction of crtB gene, which encodes phytoene synthase, and these cells were proven to acquire the resistance against carcinogenesis. " 05/01/1991 - "The carotenoids beta-carotene, canthaxanthin and phytoene also inhibit UV-B carcinogenesis. " 08/01/2013 - "In this study, we investigated the effects of supplementing tomato extract (TE), which contains mainly lycopene (LY) and less amounts of its precursors, phytoene (PT) and phytofluene (PTF) against high-fat-diet related hepatic inflammation and lipid profiles, and carcinogenesis. "
5.	Obesity 05/17/2020 - "The inhibition of α-amylase, α-glucosidase, and pancreatic lipase activities appeared to be better correlated with the carotenoid content, which warrants further studies of the possible anti-diabetic and anti-obesity actions of the major carotenoids found in the fruits (lycopene, phytoene, and lutein). "

Related Drugs and Biologics

1.	Lycopene
2.	phytofluene
3.	Carotenoids (Carotene)
4.	Lutein
5.	Lipids
6.	Lipase (Acid Lipase)
7.	Glucosidases
8.	Amylases
9.	beta Carotene (Betacarotene)
10.	Canthaxanthin

Related Therapies and Procedures

1.	Prostatectomy (Retropubic Prostatectomy)
2.	Chemoprevention