saccharopine

lysine precursor in the aminoadipic acid-lysine pathway in yeast; minor descriptor (75-85); on-line & Index Medicus search LYSINE/analogs & derivatives (75-85); RN given refers to (L)-isomer

Also Known As:

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Guo, Weixiang: 1 article (01/2022)
2.	Guo, Ye: 1 article (01/2022)
3.	Jian, Youli: 1 article (01/2022)
4.	Wang, Min: 1 article (01/2022)
5.	Wang, Xin: 1 article (01/2022)
6.	Wu, Junjie: 1 article (01/2022)
7.	Yang, Chonglin: 1 article (01/2022)
8.	Funai, Asuka: 1 article (05/2021)
9.	Kawata, Akihiro: 1 article (05/2021)
10.	Kuhara, Tomiko: 1 article (05/2021)

Related Diseases

1.	Hyperlysinemias (Hyperlysinemia) 01/01/2022 - "Altogether, our findings not only unravel the requirement for saccharopine degradation in neuronal development, but also provide the mechanistic insights for understanding the neurometabolic disorder of hyperlysinemia-II.SIGNIFICANCE STATEMENT The association between neurologic disorder and a pronounced biochemical abnormality in hyperlysinemia remains a challenging clinical question. " 05/01/1979 - "To complete the studies on the enzymes associated with familial hyperlysinemia, saccharopine oxidoreductase was partially purified from human liver and characterized. " 01/01/1970 - "Recent findings that lysine degradation in mammals may involve saccharopine and that the human diseases, hyperlysinemia and saccharopinuria, may be due to metabolic blocks in this route of lysine degradation suggest the ly(1-1) and ly(9-1) yeast mutants as models for the human condition and its possible euphenic treatment."
2.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "These findings provide a foundation for future research aimed at isolating saccharopine and conducting in vivo studies to evaluate its potential as a targeted therapy for breast cancer. " 01/01/2023 - "We aimed to assess the antiproliferative effects of TCF extract on breast cancer cells and explore the potential role of saccharopine, a phytochemical found in TCF, as an anticancer agent. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 05/01/2021 - "Saccharopinuria is generally considered a benign metabolic variant, but our case showed elevated lysine and saccharopine levels causing ornithine circuit damage, mitochondrial dysfunction, and autophagy disorders. "
4.	Reperfusion Injury 01/01/2020 - "Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection."
5.	Reye Syndrome (Reye's Syndrome) 07/01/1990 - "During attacks, these patients excreted alpha-keto-adipic, alpha-hydroxy-adipic, and alpha-aminoadipic acids, branched-chain keto acids and saccharopine in addition to lactic, pyruvic, and dicarboxylic acids characteristic of Reye syndrome. "

Related Drugs and Biologics

1.	Oxidoreductases (Dehydrogenase)
2.	Enzymes
3.	Lysine (L-Lysine)
4.	Saccharopinuria
5.	Phytochemicals
6.	Urea (Carbamide)
7.	Ornithine
8.	Kynurenine
9.	Keto Acids
10.	Dicarboxylic Acids

Related Therapies and Procedures

1.	Therapeutics