tylocrebrine

major descriptor (72-84); on-line search ISOQUINOLINES (72-84); Index Medicus search TYLOCREBRINE (72-84); RN given refers to (R)-isomer; an indolizidine; isomer of APORPHINES

Also Known As:

tylocrebrine, (S)-isomer

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        tylocrebrine: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - tylocrebrine: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        tylocrebrine: 3

Experts

1.	Georg, Gunda I: 1 article (08/2015)
2.	Guru, Bharath Raja: 1 article (08/2015)
3.	Gurvich, Vadim J: 1 article (08/2015)
4.	Kirtane, Ameya R: 1 article (08/2015)
5.	Lis, Lev G: 1 article (08/2015)
6.	Panyam, Jayanth: 1 article (08/2015)
7.	Wong, Henry L: 1 article (08/2015)
8.	Gater, Deborah: 1 article (08/2010)

Related Diseases

1.	Neoplasms (Cancer) 08/03/2015 - "To improve the safety and potency of tylocrebrine, we formulated the drug in polymeric nanoparticles targeted to the epidermal growth factor receptor (EGFR) overexpressed on several types of tumors. "
2.	Cardiovascular Diseases (Cardiovascular Disease) 08/01/2010 - "This conference report highlights selected presentations on Hsp90 inhibitors and Hsp70 inducers, such as KU-32 and KU-174 (University of Kansas); natural products in drug design, such as minnelide (University of Minnesota) and tylocrebrine; novel compounds from Merck for metabolic and cardiovascular diseases, such as MK-7725, a series of DDP4 inhibitors and KV1.5 ion channel antagonists; and the discovery of the VEGFR2 kinase inhibitor AMG-429 (Amgen Inc)."
3.	Ascites 04/05/1968 - "Inhibition of protein synthesis in Ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine."

Related Drugs and Biologics

1.	ErbB Receptors (EGF Receptor)
2.	Proteins (Proteins, Gene)
3.	Phosphotransferases (Kinase)
4.	Ion Channels (Ion Channel)
5.	Alkaloids
6.	14-O-phosphonooxymethyltriptolide disodium salt
7.	phenanthrene
8.	cryptopleurine
9.	tylophorine