sintamil

has pronounced sedative properties, but otherwise resembles imipramine; minor descriptor (77-84); on-line & Index Medicus search DIBENZOXAZEPINES (77-84); RN given refers to mono-HCl

Also Known As:

10-(3-(dimethylamino)propyl)-2-nitrodibenz(b,f)(1,4)-oxazepin-11(10H)-one; 233-Go; 2330 Go; nitroxazepine

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzoxazepines: 1
      - sintamil: 4

Related Diseases

1.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/31/1986 - "The in vitro effect of sintamil, as a modulator alone and in combination with hydroxyurea (HU), on cytotoxicity was studied in 16 cases of human chronic myeloid leukemia (CML). " 10/31/1986 - "Augmentation of hydroxyurea cytotoxicity by sintamil in human chronic myeloid leukemia cells." 01/01/1988 - "Modulation of sensitivity to mitoxantrone in human chronic myeloid leukemia cells by the antidepressant sintamil."
2.	Neoplasms (Cancer) 01/01/1987 - "The implications of the present investigations are promising, leaving hope for the utility of nitroxazepine hydrochloride in restoring drug sensitivity in adriamycin-resistant tumors."
3.	Leukemia 01/01/1987 - "The survival of mice bearing adriamycin-resistant P388 murine leukemia cells treated in vitro with nitroxazepine hydrochloride, adriamycin and a combination of the two drugs was also investigated. " 01/01/1987 - "Attempts were made to reverse the acquired resistance of P388 murine leukemia utilizing non-toxic concentration of nitroxazepine hydrochloride, an antidepressant. " 01/01/1987 - "Restoration of drug sensitivity by nitroxazepine hydrochloride in P388 murine leukemia cells resistant to adriamycin." 01/01/1987 - "The results show that treatment of these cells with nitroxazepine hydrochloride significantly enhanced (1) the intracellular accumulation of adriamycin, (2) inhibition of DNA biosynthesis, and (3) the survival of mice transplanted with adriamycin-resistant P388 murine leukemia cells treated in vitro with a combination of nitroxazepine hydrochloride and adriamycin. "
4.	Hepatitis 04/01/1986 - "Hepatitis following nitroxazepine therapy."

Related Drugs and Biologics

1.	Antidepressive Agents (Antidepressants)
2.	Mitoxantrone (Novantrone)
3.	Hydroxyurea (Hydrea)
4.	Doxorubicin (Adriamycin)
5.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics