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mannosulfan (R-52)

minor descriptor (75-84); on-line & Index Medicus search METHANESULFONATES (75-84)

Also Known As:

R-52; 1,2,5,6-tetramethanesulfonyl-D-mannitol; Zitostop; tetramesylmannite

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Alkanesulfonic Acids
        Alkanesulfonates: 9
        Mesylates: 334
        mannosulfan: 7
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfonic Acids: 1605
      - Alkanesulfonic Acids
        Alkanesulfonates: 9
        Mesylates: 334
        mannosulfan: 7

Related Diseases

1.	Neoplasms (Cancer) 01/01/1972 - "[Mutations induced in vitro by an alkylating agent (zitostop) in malignant diseases and in syndromes predisposing to malignancy]." 01/01/1979 - "Since increased antitumor effectiveness of mannosulfan was accompanied by its decreased toxicity, it may be concluded that insulin causes selective cummulation of the cytostatic only in some tissues, among others, in the tumor." 10/01/1983 - "Cytostatic drugs under clinical trial [Elobromol (DBD), Myelobromol (DBM), Lycurim (LY), Zitostop (ZI)], others in preclinical analysis [dianhydrogalactitol (DAG), 3,4-diacetyldianhydrogalactitol (DiacDAG), 3,4-disuccinyldianhydrogalactitol (DisuDAG)], and compounds without any known antitumor effect in transplantable tumors [1-bromo-3,6-anhydrodulcitol (BAD), 1,2-epoxi-3,6-anhydrodulcitol (EAD)] were examined. "
2.	Polycythemia Vera 01/01/1976 - "[Zitostop in the treatment of erythremia]." 04/19/1970 - "[Therapy of polycythemia rubra vera using Zitostop]."
3.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/26/1971 - "[Zitostop therapy of chronic myeloid leukemia]."
4.	Lymphoma (Lymphomas) 03/15/1976 - "[Zitostop in cyclical treatment of malignant lymphoma in combination with vinblastine, natulan and prednisone]."

Related Drugs and Biologics

1.	Cytostatic Agents
2.	Vinblastine (Vinblastine Sulfate)
3.	Procarbazine (Matulane)
4.	Prednisone (Sone)
5.	Mitobronitol
6.	Insulin (Novolin)
7.	Dianhydrogalactitol
8.	Alkylating Agents
9.	3,4-disuccinyl 1,2-5,6-dianhydrogalactitol
10.	ritrosulfan

Related Therapies and Procedures

1.	Therapeutics