fonazine (dimetotiazine)

has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions; minor descriptor (75-84); on-line & Index Medicus search PHENOTHIAZINES (75-84); RN given refers to parent cpd
Also Known As:
dimetotiazine; 10-(2-(dimethylamino)propyl)-N,N-dimethylphenothiazine-2-sulfonamide monomethane sulfonate; Banistyl; Migristene; Promaquid; Rhône-Poulenc Rorer brand of fonazine; dimethothiazine; dimetotiazine mesilate; fonazine mesylate; fonazine monomesylate
Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1. Muscle Spasticity (Spastic)
2. Migraine Disorders (Migraine)
3. Headache (Headaches)
4. Decerebrate State
07/01/1970 - "Higher doses of dimethothiazine had little further significant effect on the discharge frequency.3. The discharge frequency recorded from de-efferented muscle spindles in soleus of the decerebrate cat were similar to the discharge frequencies obtained in preparations with intact ventral roots which had received a high dose of dimethothiazine.4. Dimethothiazine had little significant effect on the discharge frequency of afferent fibres from muscle spindles in the soleus muscle of decerebrate preparations where the ventral roots were cut.5. These effects of dimethothiazine on muscle spindle activity were not related to any changes in blood pressure of the decerebrate cat.6. Dimethothiazine appears to reduce the effects of both the dynamic and static fusimotor fibres on the spindle.7. The doses of dimethothiazine which effect spindle discharge frequency are similar to those required to reduce decerebrate rigidity."
01/01/1974 - "When administered orally M & B 18,706 and chlorpromazine were equi-potent in reducing rigidity but M & B 18,706 was less effective than chlorpromazine in producing ataxia in this species.3 In the rat, M & B 18,706 had one-quarter the potency of chlorpromazine for reducing decerebrate rigidity but had from 1/20th to 1/200th its potency in tests for sedative or tranquillizing activity.4 M & B 18,706, like dimethothiazine and chlorpromazine, had little effect on the rigidity of ischaemic decerebrate cats and failed to inhibit polysynaptic spinal reflexes.5 M & B 18,706 had intravenous potency comparable to chlorpromazine in reducing the pressor action of noradrenaline in the spinal cat."
01/01/1974 - "1 (+/-)-10-(3-Dimethylamino-2-methylpropyl)-2-valeroylphenothiazine hydrochloride (M & B 18,706) has been compared with dimethothiazine, chloropromazine, diazepam and baclofen for potency in reducing decerebrate rigidity in the cat and rat and for activity in causing ataxia or sedation.2 When given intravenously M & B 18,706 had seven times the potency of dimethothiazine and one-half the potency of chlorpromazine in reducing the rigidity of the intercollicular decerebrate cat. "
5. Neurogenic Inflammation

Related Drugs and Biologics

1. Sumatriptan (Imigran)
2. Tiapride
3. Pyrilamine (Mepyramine)
4. Norepinephrine (Noradrenaline)
5. Flunarizine
6. Diazepam (Valium)
7. Chlorpromazine (Thorazine)
8. Baclofen
9. M&B 18706