cannogenin thevetoside (peruvoside)

from Thevetia neriifolia; minor descriptor (75-84); on-line & Index Medicus search CARDENOLIDES (77-84), CARDANOLIDES (75-76); RN given refers to (3beta,5beta)-isomer

Also Known As:

peruvoside; 3 beta,14 beta-dihydroxy-19-oxo-5 beta-card-20(22)-enolide-3 alpha-L-thevetoside; encordin; Card-20(22)-enolide, 3-((6-deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy)-14-hydroxy-19-oxo-, (3beta,5beta)-

Networked: 16 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
        Cardenolides: 137
        cannogenin thevetoside: 16

Experts

1.	Azad, Neelam: 2 articles (09/2017 - 01/2017)
2.	Iyer, Anand Krishnan V: 2 articles (09/2017 - 01/2017)
3.	Kaushik, Vivek: 2 articles (09/2017 - 01/2017)
4.	Yakisich, Juan Sebastian: 2 articles (09/2017 - 01/2017)
5.	Chang, Geechen: 1 article (01/2022)
6.	Chang, Hsiuhui: 1 article (01/2022)
7.	Chen, Hueiwen: 1 article (01/2022)
8.	Chen, Jeremy Jw: 1 article (01/2022)
9.	Lai, Yihua: 1 article (01/2022)
10.	Amend, N: 1 article (10/2021)

Related Diseases

1.	Leukemia 04/22/2016 - "Thus, Peruvoside showed potent anti-leukemia effect, which may serve as a new anti-leukemia agent in the future. " 04/22/2016 - "In search of other potential anti-leukemia CGs, we found that Peruvoside, a less studied CG, is more effective than Ouabain and Digitoxin at inducing cell death in primitive myeloid leukemia cells without obvious cytotoxicity on normal blood cells. " 12/01/2016 - "In order to better understand and exploit them as cardiac ionotropes, studies are being pursued using different cardiac glycosides such as digitoxin, digoxin, ouabain, oleandrin etc. Several cardiac glycosides as peruvoside have shown promise in cancer control, especially ovary cancer and leukemia. "
2.	Heart Failure 09/26/1970 - "Oral peruvoside was also effective in the treatment of congestive heart failure when used on a short-term as well as a long-term basis. " 06/01/1992 - "[Hemodynamic studies on the effects of peruvoside on congestive heart failure]." 09/26/1970 - "Haemodynamic studies with peruvoside in human congestive heart failure." 11/01/1975 - "The response of one patient with constrictive pericarditis to parenteral peruvoside administration was similar to that seen in patients with myocardial failure. " 11/01/1975 - "Pre-ejection period index (PEPI) shortened significantly (P less than 0.01) after peruvoside in normal subjects and in patients with myocardial failure, but not in constrictive pericarditis. "
3.	Neoplasms (Cancer) 01/15/2020 - "To investigate the cytotoxic effect of Peruvoside and mechanism of action in human cancers. " 01/15/2020 - "Our results demonstrated that Peruvoside has the ability to inhibit cancer cell proliferation by modulating the expression of various key proteins involved in cell cycle arrest, apoptosis, and autophagic cell death. " 01/15/2020 - "Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers." 01/01/2022 - "Our findings suggest that peruvoside suppresses non-small-cell lung carcinoma (NSCLC) malignancy by downregulating multiple Src-related pathways and could serve as a potential base molecule for developing new anticancer drugs and therapeutic strategies for lung cancer." 09/01/2017 - "Cardiac glycosides demonstrate such multimodal effects on cancer cell survival, and our aim was to evaluate the effect of two naturally occurring monosaccaridic cardiac glycosides-Convallatoxin and Peruvoside on lung cancer cells. "
4.	Ovarian Neoplasms (Ovarian Cancer) 12/01/2016 - "In order to better understand and exploit them as cardiac ionotropes, studies are being pursued using different cardiac glycosides such as digitoxin, digoxin, ouabain, oleandrin etc. Several cardiac glycosides as peruvoside have shown promise in cancer control, especially ovary cancer and leukemia. "
5.	Vomiting 05/01/1972 - "Mechanism of peruvoside-induced emesis." 06/01/1975 - "1 Peruvoside, (a glycoside obtained from the plant, Thevetia neriifolia Juss) and ouabain produce emesis in cats. " 06/01/1975 - "Chloropromazine hydrochloride, mepyramine maleate, or BOL-148 administered intravenously or intracerebro-ventricularly do not afford protection.2 Phenoxybenzamine produces partial protection against peruvoside-induced emesis.3 Haloperidol (1 mg/kg i.v.) prevents vomiting induced by peruvoside or ouabain. "

Related Drugs and Biologics

1.	Ouabain (G Strophanthin)
2.	Digitoxin
3.	Cardiac Glycosides
4.	Digoxin (Digitek)
5.	oleandrin
6.	Pyrilamine (Mepyramine)
7.	Phenoxybenzamine
8.	Haloperidol (Haldol)
9.	Glycosides
10.	convallatoxin

Related Therapies and Procedures

1.	Intravenous Administration
2.	Therapeutics