cardiolipin synthetase

catalyzes phosphatidylglycerol & CDPdiglyceride to CMP & diphosphatidylglycerol (cardiolipin); minor descriptor (75-83); on-line & Index Medicus search PHOSPHOTRANSFERASES (75-83)

Also Known As:

Networked: 14 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hatch, Grant M: 3 articles (04/2016 - 05/2002)
2.	Taylor, William A: 2 articles (08/2011 - 05/2002)
3.	Xu, Fred Y: 2 articles (08/2011 - 05/2002)
4.	Balasubramaniam, Shanti: 1 article (10/2022)
5.	Boycott, Kym M: 1 article (10/2022)
6.	Care4Rare Canada Consortium: 1 article (10/2022)
7.	Ferdinandusse, Sacha: 1 article (10/2022)
8.	Filipovska, Aleksandra: 1 article (10/2022)
9.	Fletcher, Janice: 1 article (10/2022)
10.	Geraghty, Michael T: 1 article (10/2022)

Related Diseases

1.	Fatty Liver 03/15/2019 - "Comprehensive proteomic analysis of the liver in the SME groups revealed an increase in the levels of major proteins involved in mitochondrial bioenergetics, including peroxisome proliferator-activated receptor gamma co-activator 1 alpha, mitochondrial thioredoxin, cardiolipin synthase, peroxisome proliferator-activated receptor alpha, and carnitine palmitoyltransferase I. Dietary SME improved liver function in the diet-induced fatty liver model. "
2.	Obesity 01/01/2022 - "Previous studies demonstrated that cardiolipin synthase 1 (CRLS1)/interferon-regulatory factor-2 binding protein 2 (IRF2bp2)-activating transcription factor 3 (ATF3)-adiponectin receptor 2 (AdipoR2)-adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 (APPL1)-protein kinase B (AKT/PKB)-related signaling was closely associated with obesity-induced IR-related diseases, but the correlation between exercise training alleviating obesity-induced IR and the protein levels of hepatic CRLS1/IRF2bp2-ATF3-AdipoR2-APPL1-AKT-related signaling in rats is unknown. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 10/28/2022 - "Using patient-derived fibroblasts, we characterized cardiolipin synthase 1 (CRLS1) dysfunction that impaired mitochondrial morphology and biogenesis, providing functional evidence that the CRLS1 variants cause mitochondrial disease. " 07/20/2012 - "Collectively, these results demonstrate the unanticipated role of cardiolipin synthase in maintaining physiologic membrane structure and function even under metabolic stress, thereby identifying cardiolipin synthase as a novel therapeutic target to attenuate mitochondrial dysfunction in diabetic myocardium."
4.	Hyperthyroidism 09/04/1997 - "Both cardiolipin levels and cardiolipin synthase activity are increased in hyperthyroidism and decreased in hypothyroidism suggesting regulation by thyroid hormone. " 05/04/2002 - "We previously reported that cardiac cardiolipin levels, MLCL AT and cardiolipin synthase activities were all elevated in rats made hyperthyroid by thyroxine treatment. "
5.	Hepatocellular Carcinoma (Hepatoma) 04/01/2016 - "For this purpose, we generated a cardiolipin synthase knockdown (shCLS) in HepaRG hepatoma cells showing bioenergetics features similar to primary human hepatocytes. " 01/01/2019 - "Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	PPAR gamma
3.	PPAR alpha
4.	Thioredoxins
5.	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)
6.	Phosphotransferases (Kinase)
7.	Transcription Factor 3
8.	Interferon Regulatory Factor-2 (Interferon Regulatory Factor 2)
9.	Carrier Proteins (Binding Protein)
10.	Cardiolipins (Cardiolipin)