mibolerone

prevents estrus in animals & prevents experimental lymphoid leukosis; minor descriptor (80-83); on-line & Index Medicus search NANDROLONE/AA (80-83); RN given refers to (7alpha,17beta)-isomer; structure

Also Known As:

Networked: 30 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gooderham, Nigel J: 1 article (07/2015)
2.	Koufaris, Costas: 1 article (07/2015)
3.	Powell, Chris: 1 article (07/2015)
4.	Segal, Corrinne V: 1 article (07/2015)
5.	Andò, Sebastiano: 1 article (02/2014)
6.	Barone, Ines: 1 article (02/2014)
7.	Catalano, Stefania: 1 article (02/2014)
8.	Dahlman Wright, Karin: 1 article (02/2014)
9.	De Amicis, Francesca: 1 article (02/2014)
10.	Giordano, Francesca: 1 article (02/2014)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 12/18/2005 - "Then human androgen-dependent prostate cancer cells LNCaP were used as a model to study the regulation of PTTG1 by Mibolerone. " 01/01/2002 - "In our study, LNCaP prostate cancer cells were treated with GA for 30 minutes or 24 hours, in the presence of mibolerone, a synthetic androgen. " 12/18/2005 - "The basic expression of PTTG1 in human androgen-independent prostate cancer cell lines PC3 or DU145 was even higher than that in the human androgen-dependent prostate cancer cells LNCaP treated with Mibolerone. " 05/01/1999 - "Prostate cancer cells were transiently transfected with each of the above-described expression vectors, incubated with or without androgen (mibolerone) for 48 h, and monitored for iodide uptake activity. " 08/30/1991 - "Mibolerone (dimethylnortestosterone) or 5 alpha-dihydrostestosterone (DHT) increase intracellular calcium (Ca2+i) of human prostate cancer cells (LNCaP) as early as 2 min after treatment. "
2.	Breast Neoplasms (Breast Cancer) 06/01/2008 - "Our results demonstrate that mibolerone can have both androgenic and progestagenic actions in breast cancer cells." 02/19/2014 - "Site-directed mutagenesis and deletion analysis reveal that an androgen response element (ARE), TGTTCT motif located at positions -383 and -377, is critical for mibolerone-induced ER-beta up-regulation in breast cancer cells. " 05/01/1995 - "Mibolerone action on breast cancer cell growth was similar to that of DHT, with the exception that growth stimulation of MCF-7 and MDA-MB-453 cells was only partially reversed in the presence of a 100-fold excess of hydroxyflutamide. " 07/01/1993 - "T47D breast cancer cells showed a similar effect with mibolerone, while hAR expression in normal skin fibroblasts did not respond to androgen treatment. " 06/01/2008 - "This study compared the effects of 5alpha-dihydrotestosterone (DHT) and a synthetic androgen, mibolerone, on estradiol (E(2))-induced proliferation of breast cancer cells. "
3.	Neoplasms (Cancer) 01/01/1985 - "No such tumors were found in 60 vehicle control animals or 55 animals given exaggerated doses of mibolerone. " 01/01/1978 - "These findings on immunocompetence to infectious agents are important because we have previously shown that the administration of mibolerone prevents the development of lymphoid leukosis tumors." 01/01/1985 - "A study to determine the efficacy and safety of mibolerone following prolonged oral administration in the female dog was terminated after 9.6 yr. Histopathologic examination revealed the presence of small dense tumors in the ovaries of 12 of 92 dogs given mibolerone at the approximate efficacious dose. " 07/01/1988 - "Human serum samples (10 microliters) were incubated in high ionic strength buffer (400 mM KCl) for 16 h at 0 C with [3H]Mibolerone-labeled cytosol (100-200 fmol AR) from Dunning tumors. " 08/28/1990 - "They further suggest that high affinity androgens labeled with suitable radionuclides--particularly derivatives of mibolerone (Mib) or methyltrienolone (R1881)--may be effective receptor-based imaging agents for androgen target tissues and tumors, even when patients are already receiving hormonal therapy."
4.	Tics (Tic) 12/01/1993 - "Additional studies revealed that the administration of a 1-microM dose of the L-type Ca2+ channel blocker verapamil to TIC cultures was able to partially block the inhibitory effect of mibolerone on androgen synthesis. " 12/01/1993 - "In rat thecal-interstitial cells (TIC), treatment with the synthetic androgen mibolerone has led to the documentation of an autoregulatory process for androgen production. "
5.	Atrophy 10/01/1985 - "Treatment with 0.01 or 0.1 micrograms of mibolerone caused slight or no bursal atrophy, 1 microgram caused substantial bursal atrophy, and 10 or 100 micrograms caused severe bursal atrophy at the time of hatching and at 6 weeks of age. " 01/01/1985 - "Mibolerone caused bursal atrophy in a dose-dependent manner with severe atrophy at the 10 micrograms dose, substantial atrophy at the 1 microgram dose, and very little or no atrophy at the 0.1 microgram dose. " 04/01/1980 - "Chickens fed a ration containing mibolerone at 1.5 parts per million (ppm) developed bursal atrophy by 4 weeks of age. " 04/01/1977 - "Mibolerone appears to prevent LL development by producing early bursal atrophy of key target cells. " 04/01/1977 - "The bursal lymphocytic follicles atrophied significantly with both the 1- and 4-microng doses; but, on the basis of histologic examination, atrophy was more complete with the 1-microng dose of mibolerone administered during the first 49 days of age. "

Related Drugs and Biologics

1.	Androgens
2.	Testosterone Congeners
3.	Dihydrotestosterone (Androstanolone)
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Ligands
7.	MicroRNAs (MicroRNA)
8.	Verapamil (Calan)
9.	Estradiol (Delestrogen)
10.	imidazole mustard (BIC)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Aftercare (After-Treatment)