dyclonine (Sucrets)

07/01/1992 - "Dyclonine hydrochloride--a topical agent for managing pain."
04/01/1990 - "The results showed that Dyclone provided the most pain relief. "
03/01/2021 - "EA combined with local anesthesia with dyclonine hydrochloride mucilage can alleviate side effects during gastroscopy, reduce patient pain, and improve the efficiency of the procedure."
01/01/2022 - "TRPV3 is inhibited by the local anesthetic dyclonine, traditionally used for topical applications to relieve pain and itch. "
02/01/2010 - "In 25 volunteers receiving topical dyclonine, FMA was applied to one forearm and a sham device in the other, followed by assessment of pain levels associated with application of a standardized stimulus at 5-minute intervals over an hour. "

01/01/1987 - "High pressure liquid chromatographic determination of dyclonine hydrochloride and its degradation products in cough lozenges and liquids."
05/01/1990 - "Lignocaine (40 mg) and dyclonine (8 mg) caused significant reports of oral anaesthesia but only lignocaine reduced the cough response to inhaled capsaicin, increasing the log dose of capsaicin causing three or more coughs by 162%. "
11/01/2014 - "In the present study, it was revealed that dyclonine, a major component of the cough droplets Sucrets, markedly enhances the cytotoxic effects of bortezomib and minimizes drug resistance in MM cells. "
05/01/1990 - "Ten volunteers had capsaicin cough dose responses performed before and at 10 min after inhaling placebo (ascorbic acid in saline), and the topical anaesthetics lignocaine 40 mg, and dyclonine 8 and 4 mg. The effect of the drugs on respiratory resistance (Rrs), measured using a forced oscillation technique, was measured both before and after the inhalation of a dose of capsaicin which caused less than two coughs. "

04/01/1990 - "Dyclone and viscous lidocaine with 1% cocaine provided the longest pain relief, which averaged 50 minutes This study provides objective data and defines useful guidelines for treatment of stomatitis."

03/01/2007 - "In 15 volunteers with bronchial hyperreactivity, a methacholine challenge was performed following the inhalation of lidocaine, dyclonine (which does not attenuate bronchial reactivity) or saline on three different days in a randomized, double-blind fashion. "
12/01/2002 - "Therefore, combined treatment with lidocaine and salbutamol can be recommended for awake intubation while the use of dyclonine, despite its excellent and longer lasting topical anesthesia, may be contraindicated in patients with bronchial hyperreactivity."
03/01/2001 - "Therefore, the authors tested the effect of dyclonine, lidocaine, and ropivacaine inhalation on histamine-induced bronchospasm in 15 volunteers with bronchial hyperreactivity. "

02/01/1986 - "Dyclonine hydrochloride, local anaesthetic allergic contact dermatitis."
02/01/1985 - "Dermatologists should recognize that 1% dyclonine hydrochloride gel can cause allergic contact dermatitis that can masquerade as widespread herpes simplex labialis."
02/01/1985 - "Allergic contact dermatitis to dyclonine hydrochloride simulating extensive herpes simplex labialis."
02/01/1985 - "Two patients developed allergic contact dermatitis to 1% dyclonine hydrochloride gel, a nonprescription topical anesthetic widely marketed for the symptomatic treatment of herpes simplex labialis. "