phenesterin

alkylating agent; major descriptor (73-83); on-line search NITROGEN MUSTARD COMPOUNDS (73-83); Index Medicus search PHENESTERIN (73-83); structure

Also Known As:

NSC 104469; fenesterine; phenesterine

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        phenesterin: 5

Related Diseases

1.	Neoplasms (Cancer) 01/01/1977 - "In this study, ASE is compared to the parent compound phenesterin which is inactive in both of these tumor lines. " 01/01/1965 - "[The effect of phenesterin on glial tumors of the mouse brain]." 01/01/1978 - "It is concluded that under the conditions of this bioassay, phenesterin was carcinogenic in female Sprague-Dawley rats, producing adenocarcinomas of the mammary gland, and in both sexes of B6C3F1 mice, producing alveolar/bronchiolar carcinomas, hematopoietic tumors, and myocardial sarcomas." 08/01/1975 - "The effects of the following cancer chemotherapeutic agents on serum hormonal levels, estrous cycles, and endocrine organs were studied in mature, normal Sprague-Dawley rats by radioimmunoassay, vaginal smear examination, and organ weight end point: estradiol mustard (NSC 112259), testosterone mustard (NSC 112260), phenoestrin (NSC 104469), methotrexate (NSC 740), 5-fluorouracil (NSC 19893), vinblastine (NSC 49842), vincristine (NSC 67574), nitrogen mustard (NSC 762), and 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962). "
2.	Sarcoma (Soft Tissue Sarcoma) 01/01/1978 - "It is concluded that under the conditions of this bioassay, phenesterin was carcinogenic in female Sprague-Dawley rats, producing adenocarcinomas of the mammary gland, and in both sexes of B6C3F1 mice, producing alveolar/bronchiolar carcinomas, hematopoietic tumors, and myocardial sarcomas."
3.	Ovarian Neoplasms (Ovarian Cancer) 06/01/1983 - "Phase II evaluation of phenesterin in patients with advanced ovarian cancer."
4.	Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar) 01/01/1978 - "It is concluded that under the conditions of this bioassay, phenesterin was carcinogenic in female Sprague-Dawley rats, producing adenocarcinomas of the mammary gland, and in both sexes of B6C3F1 mice, producing alveolar/bronchiolar carcinomas, hematopoietic tumors, and myocardial sarcomas."
5.	Body Weight (Weight, Body) 01/01/1978 - "Phenesterin was toxic to rats and mice at the doses used, as shown by reduced mean body weights and survival. " 01/01/1978 - "Groups of 35 rats of each sex were administered phenesterin at one of two doses, either 5 or 10 mg/kg body weight, three times per week for 52 weeks, then observed for an additional 32 or 33 weeks. "

Related Drugs and Biologics

1.	Vincristine (Oncovin)
2.	Vinblastine (Vinblastine Sulfate)
3.	Methotrexate (Mexate)
4.	Mechlorethamine (Nitrogen Mustard)
5.	Fluorouracil (Carac)
6.	Carmustine (FIVB)
7.	estradiol mustard
8.	testosterone mustard