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difenoxin (difenoxin hydrochloride)
was EP to DIPHENOXYLATE (77-81); RN given refers to parent cpd
Also Known As:
difenoxin hydrochloride
; difenoxin hydrochloride, 14C-labeled; diphenoxylic acid
Networked:
5
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Drug Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperidines: 17
Isonipecotic Acids: 1
Diphenoxylate: 130
difenoxin: 5
Heterocyclic Acids
Isonipecotic Acids: 1
Diphenoxylate: 130
difenoxin: 5
Experts
1.
Scarlett, Yolanda
: 1 article (01/2004)
Related Diseases
1.
Diarrhea
01/01/1979 - "
In an open multicentre study including 259 patients with acute or chronic diarrhea of various etiology, difenoxin hydrochloride removed the complaints in 63--75% of the cases and improved them in some further 20%.
"
11/20/1976 - "
Difenoxin hydrochloride was tested in two studies involving 220 patients with acute diarrhea and 41 patients with chronic diarrhea respectively.
"
01/01/1979 - "
[Treatment of diarrhea with difenoxin hydrochloride in children (author's transl)].
"
11/20/1976 - "
The new antidiarrheal drug difenoxin hydrochloride is a preparation with a broad range of action; it is suitable for symptomatic treatment of acute and chronic diarrhea of varying etiology and may be administered as additional medication in cases of specific intestinal infections accompanied by diarrhea.
"
01/01/2004 - "
Antidiarrheal agents (including loperamide, diphenoxylate, and difenoxin) and the tricyclic antidepressant amitriptyline improve continence in patients with diarrhea-associated incontinence.
"
2.
Infections
11/20/1976 - "
The new antidiarrheal drug difenoxin hydrochloride is a preparation with a broad range of action; it is suitable for symptomatic treatment of acute and chronic diarrhea of varying etiology and may be administered as additional medication in cases of specific intestinal infections accompanied by diarrhea.
"
3.
Gastroesophageal Reflux (GERD)
07/01/1976 - "
Difenoxin, a new antidiarrheal agent, had no effect on lower esophageal sphincter pressure in man when given at an oral dose of 2 mg. Thus, this drug does not appear to cause or aggravate symptoms of gastro-esophageal reflux and may safely be used in reflux patients.
"
Related Drugs and Biologics
1.
Antidiarrheals
2.
Loperamide (Imodium)
3.
Diphenoxylate
4.
Tricyclic Antidepressive Agents (Tricyclic Antidepressants)
5.
Amitriptyline (Elavil)