|1.||Sreenath, Kadreppa: 2 articles (03/2010 - 01/2007)|
|2.||Chattopadhyay, Samit: 2 articles (03/2010 - 01/2007)|
|3.||Pavithra, Lakshminarasimhan: 2 articles (03/2010 - 01/2007)|
|4.||Celejewska-Wójcik, N: 1 article (12/2015)|
|5.||Oleś, K: 1 article (12/2015)|
|6.||Szczeklik, A: 1 article (12/2015)|
|7.||Gielicz, A: 1 article (12/2015)|
|8.||Ćmiel, A: 1 article (12/2015)|
|9.||Ignacak, M: 1 article (12/2015)|
|10.||Mastalerz, L: 1 article (12/2015)|
10/01/1996 - "Thus, PGA2 had antiviral activity, but its proinflammatory effects appeared to be more detrimental than beneficial in the treatment of herpetic keratitis."
10/01/1996 - "Despite favorable therapeutic indices in cultured cells, PGA2 was not effective as a therapeutic agent in the treatment of herpetic keratitis in a rabbit model. "
10/01/1996 - "Assessment of antiviral activity, efficacy, and toxicity of prostaglandin A2 in a rabbit model of herpetic keratitis."
01/01/2007 - "Our studies provide a mechanistic insight into the regulation of tumor suppressor protein SMAR1 by a cancer therapeutic PGA2, that leads to repression of Cyclin D1 gene."
03/01/1996 - "Our results highlight the chemotherapeutic potential of PGA2, particularly for suppressing growth of tumors lacking p53 function."
02/01/2000 - "moniliforme) which is implicated in the high incidence of oesophageal cancer, were determined on AA, PGE2 and PGA2 WHCO3 treated cells. "
11/19/1998 - "Prostaglandin (PG) A2 (PGA2) and Delta12-PGJ2 have potent antiproliferative activity on various tumor cell growths in vitro. "
12/01/1996 - "Prostaglandin A2 (PGA2) suppresses tumor growth in vivo, is potently antiproliferative in vitro, and is a model drug for the study of the mammalian stress response. "
12/01/1996 - "Our previous studies using breast carcinoma MCF-7 cells suggested that p21(Waf1/Cip1) induction enabled cells to survive PGA2 exposure. "
04/01/2005 - "Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells."
03/01/1996 - "Here we demonstrate that treatment of breast carcinoma MCF-7 cells with PGA2 leads to G1 arrest associated with a dramatic decrease in the levels of cyclin D1 and cyclin-dependent kinase 4 (cdk4) and accompanied by an increase in the expression of p21. "
03/01/1996 - "Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2."
01/01/1988 - "The inhibitory effects of various prostaglandins (PGA2, PGD2 and PGE2) on the growth of human gingival carcinoma cell line Ca 9-22 and human cervical carcinoma cell line HeLa were studied in vitro. "
|4.||Melanoma (Melanoma, Malignant)
06/15/1999 - "Secondly, after exposing IGR-39 human melanoma cells to PGA2, both diastereoisomers of the PGA2-glutathione conjugate are excreted into the medium, although with a clear excess of the S-form, due to its preferential formation by the GSTP1-1 present in the cells. "
04/01/1983 - "Prostaglandin A2 was much less effective than PGA1 in inhibiting melanoma colony formation. "
06/15/1999 - "The glutathione-related metabolism of PGA2 was therefore investigated both with purified glutathione S-transferase P1-1 (GSTP1-1) and with IGR-39 human melanoma cells. "
04/01/1986 - "However, against human melanoma cells, PGD2 was much more active than PGA1, whereas PGA2 was inactive. "
01/01/1983 - "The B-16 melanoma cell line which we used synthesized arachidonic acid metabolites which comigrated with PGA2, PGD2, PGE2, and PGF2 alpha on a thin layer chromatography system."
|5.||Dehydration (Water Stress)
11/01/1977 - "To establish a quantitative assessment of 1 as a chemically stable and orally active prodrug of 2, the hydrolysis of 1 to 2 and the subsequent dehydration of 2 to prostaglandin A2 (3) were followed at 25 degrees C and six pH's ranging from 2.0 to 6.5 by means of a high-pressure liquid chromatographic procedure. "
09/14/1986 - "These results suggested that growth inhibitory effect of PGE2 was due to the metabolic dehydration of PGE2 to PGA2, and PGA2, after taken up by cells, exerted cell growth inhibition."
02/01/2005 - "However, PGE2 is known to rapidly undergo nonenzymatic dehydration to produce PGA2, a member of the cyclopentenone PGs, which have been implicated in anti-inflammatory processes. "
12/01/1986 - "Mechanisms of deceleration by methylated cyclodextrins in the dehydration of prostaglandin E2 and the isomerization of prostaglandin A2 in aqueous solution."
05/01/2001 - "The cyclopentenone prostaglandins PGA2, PGA1, and PGJ2 are formed by dehydration within the cyclopentane ring of PGE2, PGE1, and PGD2. "
|1.||prostaglandin A2 (PGA2)
|4.||Arachidonic Acid (Vitamin F)
|5.||Protein-Tyrosine Kinases (Tyrosine Kinase)
|7.||prostaglandin A1 (PGA1)