|1.||Audrézet, Marie-Pierre: 2 articles (12/2014 - 09/2011)|
|2.||Keeler, Camille: 2 articles (05/2014 - 12/2013)|
|3.||Ehrlich, Barbara E: 2 articles (05/2014 - 12/2013)|
|4.||Hodsdon, Michael E: 2 articles (05/2014 - 12/2013)|
|5.||Kuo, Ivana Y: 2 articles (05/2014 - 12/2013)|
|6.||Menè, Paolo: 2 articles (01/2013 - 01/2006)|
|7.||Zhou, Jing: 2 articles (10/2010 - 04/2003)|
|8.||Li, Xiaogang: 2 articles (04/2010 - 04/2003)|
|9.||Ward, Christopher J: 2 articles (02/2009 - 03/2004)|
|10.||Harris, Peter C: 2 articles (02/2009 - 03/2004)|
|1.||Polycystic Kidney Diseases (Polycystic Kidney Disease)
12/01/2014 - "Here, we provide a comprehensive review of these significant advances as well as those related to disease pathogenesis models, including mutation analysis of PKD1 and PKD2 (encoding polycystin 2), current mutation detection rate, allelic heterogeneity, genotype and phenotype relationships (in terms of three different inheritance patterns: classical autosomal dominant inheritance, complex inheritance, and somatic and germline mosaicism), modifier genes, the role of second somatic mutation hit in renal cystogenesis, and findings from mouse models of polycystic kidney disease. "
12/17/2013 - "Finally, we simulate and compare experimental data fits for the binding isotherms of Ca(2+) binding to its canonical binding site (EF-hand domain) of polycystin 2, a Ca(2+)-dependent channel with relevance to polycystic kidney disease. "
05/01/2011 - "Tying TAZ and Nek1 into polycystic kidney disease through polycystin 2 levels."
04/01/2007 - "The zebrafish mutation curly up (cup) affects the zebrafish ortholog of polycystic kidney disease 2, a gene that encodes the Ca(2+)-activated non-specific cation channel, Polycystin 2. We have characterized two alleles of cup, both of which display defects in organ positioning that resemble human heterotaxia, as well as abnormalities in asymmetric gene expression in the lateral plate mesoderm (LPM) and dorsal diencephalon of the brain. "
03/01/1998 - "Immunohistochemical studies have shown that polycystin 1 and polycystin 2 are developmentally regulated and are overexpressed in polycystic kidneys. "
|2.||Autosomal Dominant Polycystic Kidney (ADPKD)
04/01/2008 - "Polycystin 2 (PC2), the protein product of the gene mutated in type 2 autosomal dominant polycystic kidney disease, has been shown to function as a nonselective cation channel in a variety of cell types. "
01/01/2006 - "TRPP2 or polycystin 2 (PC2), encoded by the PKD2 gene, is an integral protein of epithelial cilia whose mutation is associated with autosomal dominant polycystic kidney disease (ADPKD). "
09/01/2005 - "PKD2, or polycystin 2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease, belongs to the transient receptor potential channel superfamily and has been shown to function as a nonselective cation channel in the plasma membrane. "
04/01/2003 - "Mutations in polycystin 2 (PC2), a Ca(2+)-permeable cation channel, cause autosomal dominant polycystic kidney disease. "
11/01/2014 - "Mutations in either the PKD1 or PKD2 genes, which encode polycystin 1 and polycystin 2, are the underlying cause of ADPKD. "
08/01/2014 - "In zebrafish, polycystin 2 knockdown induces kidney cysts, hydrocephalus, left/right asymmetry defects, and strong dorsal axis curvature. "
01/01/2011 - "Autosomal dominant polycystic kidney disease (PKD) is an inherited disease that results from mutations in either polycystin (PKD1) or polycystin 2 (PKD2), both of which are large, complex, and multifunctional proteins whose loss results in the development of numerous fluid-filled cysts and fibrosis that compromise renal function. "
|4.||Cystic Kidney Diseases (Cystic Kidney Disease)
|5.||Autosomal Recessive Polycystic Kidney (Polycystic Kidney Disease, Infantile, Type I)
|1.||polycystic kidney disease 1 protein
|2.||Proteins (Proteins, Gene)
|5.||Small Interfering RNA (siRNA)
|7.||Calcium Channels (Calcium Channel)
|8.||Staphylococcal Protein A (A, Protein)
|9.||Immune Sera (Antisera)