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oligotide

an oligodeoxyribonucleotide of MW 4-10 kDa, obtained by controlled hydrolysis of DNA from mammalian lungs; has cardioprotective effect

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Oligonucleotides: 5145
      - Oligodeoxyribonucleotides: 2217
        oligotide: 7

Experts

1.	Baldan, N: 1 article (11/2001)
2.	Burra, P: 1 article (11/2001)
3.	Cadrobbi, R: 1 article (11/2001)
4.	Calabrese, F: 1 article (11/2001)
5.	Calò, L: 1 article (11/2001)
6.	Cardin, R: 1 article (11/2001)
7.	Chirizzi, L: 1 article (11/2001)
8.	Pettenazzo, E: 1 article (11/2001)
9.	Plebani, M: 1 article (11/2001)
10.	Rigotti, P: 1 article (11/2001)

Related Diseases

1.	Reperfusion Injury 02/01/1996 - "Protection of rat kidney from ischemia reperfusion injury by oligotide." 11/01/1997 - "Effect of L-arginine and oligotide on liver ischemia-reperfusion injury." 03/01/1996 - "Cardioprotective actions of oligotide, a single stranded polydeoxyribonucleotide complex, in myocardial ischaemia and reperfusion injury." 11/01/2001 - "The aim of this study was to investigate the effect of L-arginine, a substrate of nitric oxide synthesis, and oligotide, a promoter of prostacyclin synthesis, on liver function and morphology after warm ischemia-reperfusion injury. "
2.	Ischemia 11/01/2001 - "Warm hepatic ischemia in pigs: effects of L-arginine and oligotide treatment." 11/01/2001 - "After constructing a side-to-side portacaval shunt, ischemia was induced by clamping the hepatic hilum for 2 h above the shunt, in 19 female pigs divided into a control group (n = 7), an L-arginine treatment group (n = 6), and an oligotide treatment group (n = 6). " 01/01/1996 - "Defibrotide (a polydeoxyribonucleotide) and oligotide (an oligodeoxyribonucleotide) obtained from mammalian single-stranded DNA, have been demonstrated to have anti-ischemic activity in some experimental models of ischemia/reperfusion of kidney in rats. "
3.	Wounds and Injuries (Trauma) 01/01/1995 - "Moreover, oligotide in a concentration-dependent manner attenuated unstimulated human neutrophil adherence to either thrombin or trauma-activated SMA endothelium in vitro (p < .001). " 01/01/1995 - "Furthermore, oligotide significantly preserved superior mesenteric artery (SMA) endothelial function as seen by the relaxation response of isolated SMA rings to acetylcholine (71 +/- 5% vs. 36 +/- 5%, p < .01 compared to untreated trauma rats). "
4.	Traumatic Shock 01/01/1995 - "Thus, our data suggest that the mechanism of the protective effect of oligotide in traumatic shock is improving endothelial function and diminishing neutrophil accumulation leading to reduced tissue injury." 01/01/1995 - "The effects of oligotide, an oligodeoxyribonucleotide analog, were investigated in an experimental model of traumatic shock. " 01/01/1995 - "Beneficial effects of oligotide, a novel oligodeoxyribonucleotide, in murine traumatic shock."
5.	Necrosis 06/01/1995 - "These data suggest that Oligotide by protecting the hearts from the ischemic damage and possibly by restricting left ventricular tissue necrosis may have normalized the biological responses of this organ to isoproterenol and preserved the integrity of coronary endothelial-dependent relaxant function."

Related Drugs and Biologics

1.	Arginine (L-Arginine)
2.	Epoprostenol (Prostacyclin)
3.	Nitric Oxide (Nitrogen Monoxide)
4.	Oligodeoxyribonucleotides
5.	Polydeoxyribonucleotides
6.	Adrenergic Agents (Adrenergic Drugs)
7.	Thrombin
8.	Cholinergic Receptors
9.	Isoproterenol (Isoprenaline)
10.	Single-Stranded DNA (DNA, Single Stranded)

Related Therapies and Procedures

1.	Warm Ischemia
2.	Surgical Portacaval Shunt (Portacaval Anastomosis)