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4- ((methylnitrosoamino)- 1- (3- pyridyl)but- 1- yl)beta- omega- glucosiduronic acid

detoxification product of 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanol

Also Known As:

NNAL-Gluc; NNAL-O-glucuronide

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chung, Chi-Jung: 1 article (04/2011)
2.	Hsueh, Yu-Mei: 1 article (04/2011)
3.	Lee, Hui-Ling: 1 article (04/2011)
4.	Lin, Pinpin: 1 article (04/2011)
5.	Pu, Yeong-Shiau: 1 article (04/2011)
6.	Shiue, Horng-Sheng: 1 article (04/2011)
7.	Su, Chien-Tien: 1 article (04/2011)
8.	Yang, Hsiu-Yuan: 1 article (04/2011)
9.	Chen, Gang: 1 article (01/2009)
10.	Knipe, Ashley: 1 article (01/2009)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 06/20/2006 - "The mean ratio of NNAL-Gluc/NNAL in healthy smokers was 4.95, and 0.5 in lung cancer smokers. " 06/20/2006 - "Using high pressure liquid chromatograph (HPLC) and gas chromatograph-mass tadom (GC-MS/MS), NNAL-Gluc and NNAL in 24h urine were detected in 8 healthy smokers, 10 lung cancer smokers and 4 healthy non-smokers. " 01/01/2009 - "The ratio of NNAL-Gluc to NNAL, a possible indicator of lung cancer risk, was significantly lower in menthol versus nonmenthol smokers. " 07/27/2001 - "Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) play a crucial role in the induction of lung cancer, and NNAL-O-glucuronide formation and elimination are important steps in detoxification of these compounds. "
2.	Neoplasms (Cancer) 02/01/1997 - "Hecht et al., Cancer Epidemiol., Biomarkers & Prev., 4: 877-884, 1995), we showed that consumption of watercress, a source of phenethyl isothiocyanate (PEITC), caused an increase in urinary excretion of NNAL plus NNAL-Gluc. " 09/01/1996 - "Two biomarkers of NNK metabolism, 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing hemoglobin adducts and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide (NNAL-Gluc) in urine, were also quantified during the course of the tumor induction experiment. "
3.	Oral Leukoplakia 07/01/1996 - "Moreover, the urinary biomarkers NNAL-Gluc, NNAL, and cotinine were associated with the presence of leukoplakia, which provides biochemical support for the role of smokeless tobacco products as a cause of oral leukoplakia."
4.	Leukoplakia 07/01/1996 - "When the total levels of NNAL-Gluc, NNAL, or NNAL-Gluc + NNAL were divided into tertiles, there was a significant association between the presence of leukoplakia and increasing levels of these metabolites; a similar relationship was found between urinary cotinine and leukoplakia. " 07/01/1996 - "Moreover, the urinary biomarkers NNAL-Gluc, NNAL, and cotinine were associated with the presence of leukoplakia, which provides biochemical support for the role of smokeless tobacco products as a cause of oral leukoplakia."
5.	Carcinoma (Carcinomatosis) 04/01/2011 - "Low ratio of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol-glucuronides (NNAL-Gluc)/free NNAL increases urothelial carcinoma risk."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butan- 1- ol
3.	Glucuronides
4.	Menthol
5.	Indicators and Reagents (Reagents)
6.	Hemoglobins (Hemoglobin)
7.	Cotinine
8.	4-hydroxy-1-(3-pyridyl)-1-butanone
9.	phenethyl isothiocyanate (PEITC)
10.	nitrosamine 4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butanone