|1.||Chung, Chi-Jung: 1 article (04/2011)|
|2.||Pu, Yeong-Shiau: 1 article (04/2011)|
|3.||Hsueh, Yu-Mei: 1 article (04/2011)|
|4.||Lin, Pinpin: 1 article (04/2011)|
|5.||Yang, Hsiu-Yuan: 1 article (04/2011)|
|6.||Shiue, Horng-Sheng: 1 article (04/2011)|
|7.||Lee, Hui-Ling: 1 article (04/2011)|
|8.||Su, Chien-Tien: 1 article (04/2011)|
|9.||Lazarus, Philip: 1 article (01/2009)|
|10.||Chen, Gang: 1 article (01/2009)|
|1.||Lung Neoplasms (Lung Cancer)
06/20/2006 - "The mean ratio of NNAL-Gluc/NNAL in healthy smokers was 4.95, and 0.5 in lung cancer smokers. "
06/20/2006 - "Using high pressure liquid chromatograph (HPLC) and gas chromatograph-mass tadom (GC-MS/MS), NNAL-Gluc and NNAL in 24h urine were detected in 8 healthy smokers, 10 lung cancer smokers and 4 healthy non-smokers. "
01/01/2009 - "The ratio of NNAL-Gluc to NNAL, a possible indicator of lung cancer risk, was significantly lower in menthol versus nonmenthol smokers. "
07/27/2001 - "Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) play a crucial role in the induction of lung cancer, and NNAL-O-glucuronide formation and elimination are important steps in detoxification of these compounds. "
02/01/1997 - "Hecht et al., Cancer Epidemiol., Biomarkers & Prev., 4: 877-884, 1995), we showed that consumption of watercress, a source of phenethyl isothiocyanate (PEITC), caused an increase in urinary excretion of NNAL plus NNAL-Gluc. "
09/01/1996 - "Two biomarkers of NNK metabolism, 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing hemoglobin adducts and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide (NNAL-Gluc) in urine, were also quantified during the course of the tumor induction experiment. "
07/01/1996 - "When the total levels of NNAL-Gluc, NNAL, or NNAL-Gluc + NNAL were divided into tertiles, there was a significant association between the presence of leukoplakia and increasing levels of these metabolites; a similar relationship was found between urinary cotinine and leukoplakia. "
07/01/1996 - "Moreover, the urinary biomarkers NNAL-Gluc, NNAL, and cotinine were associated with the presence of leukoplakia, which provides biochemical support for the role of smokeless tobacco products as a cause of oral leukoplakia."
|1.||Biological Markers (Surrogate Marker)
|2.||4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butan- 1- ol
|7.||phenethyl isothiocyanate (PEITC)
|8.||4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanone