|1.||Hwang, Yu-Wen: 5 articles (02/2014 - 10/2006)|
|2.||Wegiel, Jerzy: 4 articles (02/2014 - 10/2006)|
|3.||Gong, Cheng-Xin: 3 articles (06/2015 - 01/2011)|
|4.||Adayev, Tatyana: 3 articles (03/2011 - 10/2006)|
|5.||Murakami, Noriko: 3 articles (06/2007 - 08/2006)|
|6.||Chen-Hwang, Mo-Chou: 3 articles (06/2007 - 08/2006)|
|7.||Qian, Wei: 2 articles (06/2015 - 01/2013)|
|8.||Shi, Jianhua: 2 articles (06/2015 - 01/2013)|
|9.||Iqbal, Khalid: 2 articles (06/2015 - 01/2013)|
|10.||Cao, Maohong: 2 articles (06/2015 - 01/2013)|
|1.||Down Syndrome (Down's Syndrome)
06/12/2015 - "Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) lies at the Down syndrome critical region of chromosome 21. "
02/01/2014 - "The gene encoding dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is located within the Down syndrome (DS) critical region of chromosome 21. "
01/01/2014 - "Substantial evidence implicates DYRK1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A) as a candidate gene responsible for altered neuronal development and brain abnormalities in Down syndrome. "
01/01/2013 - "Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Dyrk1A) is overexpressed in Down syndrome and may play a critical role in the early onset of tau pathology in this disease. "
12/02/2008 - "The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4."
|2.||Mental Retardation (Idiocy)
10/01/2015 - "The dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene, located on chromosome 21q22.13 within the Down syndrome critical region, has been implicated in syndromic intellectual disability associated with Down syndrome and autism. "
01/01/2010 - "Trisomy 21-linked Dyrk1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) overexpression is implicated in pathogenic mechanisms underlying mental retardation in Down syndrome (DS). "
03/15/2014 - "Several studies indicate that aberrant expression of the kinase Dyrk1a (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is implicated in Down syndrome, in particular in the onset of mental retardation. "
07/01/2008 - "Recent studies have shown that several pro-apoptotic kinases, including protein kinase C (PKC)delta, Abelson murine leukemia viral oncogene homolog 1 (c-Abl) and dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2), undergo nuclear-cytoplasmic shuttling in response to DNA damage. "
01/01/2011 - "Recent studies indicate that the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) gene, which is located on chromosome 21q22.2 and is overexpressed in Down syndrome (DS), may play a significant role in developmental brain defects and in early onset neurodegeneration, neuronal loss and dementia in DS. "
|5.||Alzheimer Disease (Alzheimer's Disease)
05/01/2015 - "Inhibition of the dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is a new high-potential therapeutic approach for Alzheimer disease. "
01/01/2009 - "As dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for AD. "
08/01/2015 - "Dysregulation of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) has been demonstrated in several pathological conditions, including Alzheimer's disease and cancer progression. "
03/25/2011 - "DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) has been shown to be involved in learning and memory impairments in Alzheimer disease and Down syndrome. "
06/12/2015 - "Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE."
|2.||Protein Kinase C
|4.||Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
|6.||Small Interfering RNA (siRNA)
|7.||Protein Kinases (Protein Kinase)
|10.||Calmodulin (Calcium-Dependent Activator Protein)
|1.||Drug Therapy (Chemotherapy)