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TEV protease

Also Known As:

tobacco etch virus protease

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        TEV protease: 6

Experts

1.	Kapust, R B: 2 articles (09/2003 - 12/2001)
2.	Waugh, D S: 2 articles (09/2003 - 12/2001)
3.	Bhatia, Sangeeta N: 1 article (01/2021)
4.	Binder-Nissim, Adina: 1 article (01/2021)
5.	Fleming, Heather E: 1 article (01/2021)
6.	He, Jiang: 1 article (01/2021)
7.	Lu, Timothy K: 1 article (01/2021)
8.	Nissim, Lior: 1 article (01/2021)
9.	Soleimany, Ava P: 1 article (01/2021)
10.	Alcaine, S D: 1 article (10/2015)

Related Diseases

1.	Autolysis 09/01/2003 - "The crystal structures of two mutants of TEV protease, active autolysis-resistant mutant TEV-S219D in complex with the proteolysis product, and inactive mutant TEV-C151A in complex with a substrate, have been determined at 1.8 and 2.2 A resolution, respectively. " 12/01/2001 - "Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency." 07/01/2005 - "Data suggest that TEV protease could be inhibited by the peptide product of autolysis. " 12/27/2002 - "The crystal structures of two TEV protease mutants, inactive C151A and autolysis-resistant S219D, have now been solved at 2.2- and 1.8-A resolution as complexes with a substrate and product peptide, respectively. "
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2021 - "We applied our integrated sense-and-respond system in a mouse model of disseminated ovarian cancer, where we demonstrated measurement of circuit-specific TEV protease activity both in vivo using exogenously administered nanoparticle sensors and ex vivo using quenched fluorescent probes. " 01/01/2021 - "Specifically, we designed an AND-gate gene circuit that integrates the activity of two ovarian cancer-specific synthetic promoters to drive the expression of a heterologous protein output, secreted Tobacco Etch Virus (TEV) protease, exclusively from within tumor cells. "
3.	Neoplasms (Cancer) 01/01/2021 - "Specifically, we designed an AND-gate gene circuit that integrates the activity of two ovarian cancer-specific synthetic promoters to drive the expression of a heterologous protein output, secreted Tobacco Etch Virus (TEV) protease, exclusively from within tumor cells. "
4.	Infections 10/01/2015 - "Here we demonstrate the successful (i) modification of T7 bacteriophage to carry tobacco etch virus (TEV) protease; (ii) expression of TEV protease by Escherichia coli following infection by our modified T7, an average of 2000 units of protease per phage are produced during infection; and (iii) proof-of-principle detection of E. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Proteins (Proteins, Gene)
3.	Peptide Hydrolases (Proteases)
4.	Fluorescent Dyes (Fluorescent Probes)