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4-(2' methoxyphenyl)- 1- (2'- (N- (2''- pyridinyl)- 4- fluorobenzamido)ethyl)piperazine
Also Known As:
4-MPPF; p-MPPF
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Aminopyridines: 77
4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine: 3
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Aminopyridines: 77
4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine: 3
Piperazines: 26
4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine: 3
Experts
1.
Huang, W J
: 1 article (05/2000)
2.
Lee, C Y
: 1 article (05/2000)
3.
Liau, C S
: 1 article (05/2000)
4.
Yau, S M
: 1 article (05/2000)
Related Diseases
1.
Hypothermia
05/01/1996 - "
No hypothermia or reciprocal forepaw treading was produced by either drug when given at doses as high as 10 mg/kg. Neither p-MPPI nor p-MPPF (10 mg/kg) given alone significantly altered the ratio of 5-HIAA/5-HT in the hippocampus or striatum.
"
01/01/1995 - "
The effects of two putative 5-HT1A antagonists, 4-(2'-methoxyphenyl)-1- [2'-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI) and 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine (p-MPPF), were examined in vivo in two tests of postsynaptic 5-HT1A receptor activation, hypothermia and reciprocal forepaw treading, in the rat.
"
05/01/1996 - "
p-MPPI [4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido] ethylpiperazine] and p-MPPF [4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine] competitively antagonized 5-HT1A receptor activation in the rat, as measured by hypothermia, forepaw treading and 5-HT turnover; they exhibited to partial agonist activity on any of these measures.
"
2.
Hyperglycemia
05/01/2000 - "
Finally, ketanserin (a 5-HT(2A) receptor antagonist), but not p-MPPF (a 5-HT(1A) receptor antagonist), GR 55562 (a 5-HT(1B/1D) receptor antagonist), SB 206553 (a 5-HT(2B/2C) receptor antagonist), or tropisetron (a 5-HT(3) receptor antagonist), was able to block 5-HT-induced hyperglycemia.
"
Related Drugs and Biologics
1.
5-HT1A Serotonin Receptor
2.
Piperazine
3.
4- (2'- methoxyphenyl)- 1- (2'- (N- (2''- pyridinyl)- 4- iodobenzamido)ethyl)piperazine
4.
Serotonin (5 Hydroxytryptamine)
5.
Ketanserin
6.
Tropisetron (Navoban)
7.
3- (3- (dimethylamino)propyl)- 4- hydroxy- N- (4- (4- pyridinyl)phenyl)benzamide
8.
SB 206553