MHC class I-related chain A

a highly diverged MHC class I gene product; GenBank X92841

Also Known As:

MHC class I chain related gene A protein; MHC class I polypeptide-related sequence A protein, human; MICA antigen; MICA protein, human; Major Histocompatibility Complex class I-related chain protein A; PERB11.1 protein, human

Networked: 43 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hayashi, Norio: 6 articles (06/2010 - 02/2003)
2.	Takehara, Tetsuo: 6 articles (06/2010 - 02/2003)
3.	Tatsumi, Tomohide: 6 articles (06/2010 - 02/2003)
4.	Miyagi, Takuya: 5 articles (06/2010 - 02/2003)
5.	Kanto, Tatsuya: 5 articles (10/2009 - 02/2003)
6.	Spies, Thomas: 5 articles (04/2009 - 02/2003)
7.	Kohga, Keisuke: 3 articles (06/2010 - 08/2008)
8.	Hiramatsu, Naoki: 3 articles (10/2009 - 12/2005)
9.	Groh, Veronika: 3 articles (04/2009 - 02/2003)
10.	Jinushi, Masahisa: 3 articles (12/2005 - 02/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Soluble MHC class I-related chain A (sMICA) and B (sMICB) play a critical role tumor evolution and poor prognosis through an immune evasion mechanism. " 06/01/2015 - "Serum levels of soluble MHC class I-related chain A (sMICA) is related with the prognosis of various types of cancer. " 03/01/2013 - "Serum levels of soluble MHC class I-related chain A (sMICA) are related with the prognosis of various types of cancer; however, few studies on the prognostic value of sMICA in hepatocellular carcinoma (HCC) have been reported. " 01/01/2016 - "Major histocompatibility complex (MHC) class I-related chain A/B (MICA/B) is a type of stress-induced molecule that plays an important role in tumor surveillance. " 01/01/2009 - "Cutting edge: down-regulation of MHC class I-related chain A on tumor cells by IFN-gamma-induced microRNA."
2.	Breast Neoplasms (Breast Cancer) 03/01/2012 - "In this study, we demonstrate that HER2/HER3 signaling regulates the expression of MHC class I-related chain A and B (MICA and MICB) in breast cancer cell lines. " 01/01/2022 - "In this study, the profiling of the expression of major histocompatibility complex (MHC) class I-related chain A and B (MICA/B) in human breast cancer tumor tissue, saliva, and urine samples of breast cancer patients and control is carried out. "
3.	Hepatocellular Carcinoma (Hepatoma) 12/01/2005 - "Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas." 10/15/2009 - "Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma." 03/01/2013 - "Serum levels of soluble MHC class I-related chain A (sMICA) are related with the prognosis of various types of cancer; however, few studies on the prognostic value of sMICA in hepatocellular carcinoma (HCC) have been reported. " 08/01/2008 - "Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma." 01/01/2014 - "Loss of expression of MHC class I-related chain A (MICA) is a frequent event and predicts poor survival in patients with hepatocellular carcinoma."
4.	Chagas Disease (American Trypanosomiasis) 01/01/2021 - "The objective of this study was to investigate whether the MICA (MHC class I-related chain A) and KIR (killer cell immunoglobulin-like receptors) polymorphisms are associated with the cardiac and digestive clinical forms of chronic Chagas disease. "
5.	Infections 01/01/2021 - "Here, we show that HAdV-F41 infection of human intestinal HCT116 cells upregulated the expression of MHC class I-related chain A (MIC A) and MIC B relative to uninfected cells. " 05/01/2008 - "Dendritic cells in HCV infection are unresponsive to interferon (IFN)-alfa, thus failing to enhance MHC class-I related chain A/B and subsequent NK cell activation. " 04/01/2007 - "To investigate the correlation between MHC class I-related chain A (MICA) gene *008 allele and human cytomegalovirus (HCMV) infection. " 11/15/2003 - "Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection." 10/01/2005 - "Infection of monocytes up-regulated expression of the NKG2D ligand, UL-16 binding protein (ULBP)1, but not expression of ULBP2, ULBP3, or MHC class I-related chain A or chain B. "

Related Drugs and Biologics

1.	mica
2.	KIR Receptors
3.	Ligands
4.	Proteins (Proteins, Gene)
5.	NK Cell Lectin-Like Receptor Subfamily K
6.	Fas Ligand Protein (Fas Ligand)
7.	Interleukin-10 (Interleukin 10)
8.	Transforming Growth Factor beta (TGF-beta)
9.	Valproic Acid (Depakote)
10.	Membrane Proteins (Integral Membrane Proteins)

Related Therapies and Procedures

1.	Lung Transplantation
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)