conophylline

01/01/2019 - "We previously reported that a novel natural compound conophylline (CnP) extracted from the leaves of a tropical plant reduced liver and pancreatic fibrosis by suppression of stellate cells. "
12/28/2018 - "Taken together, our results indicate that conophylline may be a useful inhibitor of ECM formation in fibrosis."
04/01/2018 - "Later, fibrosis of the pancreatic islets was found to be greatly reduced by conophylline in the pancreatic islets. "
04/01/2013 - "We have also isolated from the leaves of Ervatamia microphylla conophylline, a compound that induces differentiation of beta cells from the precursor cells and was recently found to suppress islet fibrosis in diabetes model rats."
02/01/2012 - "Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats."

01/01/2006 - "More importantly, conophylline is effective in reversing hyperglycemia in neonatal streptozotocin-treated rats, and both the insulin content and the beta cell mass are increased by conophylline. "

04/01/2018 - "Further study indicated that conophylline inhibited non-alcoholic steatohepatitis in the model mice. "
01/01/2017 - "Conophylline inhibits non-alcoholic steatohepatitis in mice."

01/01/2021 - "Conophylline was found to suppress secretions of various inflammatory cytokines by pancreatic cancer-associated fibroblasts. "
12/01/2004 - "We isolated conophylline from the leaves of Ervatamia microphylla as an agent that induce insulin production in rat pancreatic acinar carcinoma cells."
10/01/2003 - "Induction of insulin production in rat pancreatic acinar carcinoma cells by conophylline."
01/01/2019 - "Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts."
03/01/2010 - "We previously found that conophylline, an alkaloid isolated from the leaves of Ervatamia microphylla, induced beta-cell differentiation in rat pancreatic acinar carcinoma cells and in cultured fetal rat pancreatic tissue and that it also decreased the blood glucose level in streptozotocin-treated fetal rats. "

08/23/2013 - "All compounds except for 3 were evaluated for their cytotoxicity against five human cancer cell lines; conophylline showed significant bioactivity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC₅₀ values of 0.17, 0.35, 0.21, 1.02, and 1.49 μM, respectively."
01/01/2019 - "The bisindoles (1-8) and the related conophylline-type bisindoles (9-13) showed pronounced in vitro growth inhibitory activity against an array of human cancer cell lines, including KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, A549, HT-29, and HCT 116 cells, with IC50 values for the active compounds in the 0.01-5 μM range."
01/01/2019 - "Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts."
01/01/2021 - "Thus, the plant-derived alkaloid conophylline inhibited cancer growth directly and indirectly, and it shows promise as a new anticancer agent."