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Bay y 1015
Also Known As:
Bay-y1015; N-(2-(4-(quinolin-2-ylmethoxy)phenyl)-2-cycloheptylacetyl) methane sulfonamide
Networked:
2
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
Bay y 1015: 2
Related Diseases
1.
Inflammation (Inflammations)
08/01/1997 - "
The study also evaluated the anti-inflammatory properties of BAY Y 1015 and its ability to inhibit ex vivo whole blood LTB4 synthesis and in vivo LTB4 synthesis in a tissue cage model of acute inflammation.
"
06/01/1997 - "
BAY y 1015 was significantly more effective in improving the qualitative histology, inhibiting the DAI, inflammation scores (37-79%), crypt scores (28-71%), MPO (49-57%) and LTB4 levels (56-63%) compared to placebo treatment at all levels of colitis.
"
06/01/1997 - "
In the advanced disease level both doses of BAY y 1015 were equipotent in inhibiting crypt and (28-32%) inflammation scores (34-36%), LTB4 (34-56%) and MPO 41-49%) compared to olsalazine.
"
2.
Colitis
06/01/1997 - "
The efficacy of BAY y 1015 in dextran sulfate model of mouse colitis.
"
06/01/1997 - "
BAY y 1015 was significantly more effective in improving the qualitative histology, inhibiting the DAI, inflammation scores (37-79%), crypt scores (28-71%), MPO (49-57%) and LTB4 levels (56-63%) compared to placebo treatment at all levels of colitis.
"
06/01/1997 - "
The aim of the study is to study the efficacy of a potent 5-lipoxygenase activating protein inhibitor (FLAP), BAY y 1015 in a dextran sulfate model of mouse colitis.
"
Related Drugs and Biologics
1.
Leukotriene B4
2.
Dextran Sulfate
3.
Proteins (Proteins, Gene)
4.
Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
5.
olsalazine (Dipentum)
Related Therapies and Procedures
1.
Culture Diffusion Chambers