N- nitroso- N- (3- keto- 1,2- butanediol)- 3'- nitrotyramine

07/01/2000 - "In this study, a two-stage skin carcinogenesis protocol was used to promote CD-1 mouse skin carcinogenesis using NO-NTA. "
08/01/1998 - "These results indicate that NO-NTA is a new tumour promoter and may induce tumour promotion by two-stage oncogenesis. "

07/01/2000 - "However, no tumors were observed in mice treated with BaP or treated with NO-NTA alone. "
01/01/1995 - "In addition, C3H10T1/2 cells were treated with NO-NTA and, following addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) as promotor, the increase of transformed foci indicated that NO-NTA could possibly be an initiator [corrected] of TPA tumor promotion. "
07/01/2000 - "The NO-NTA-promoted tumors that were observed histologically in mice showed well-differentiated squamous cell carcinoma with invasion into the subcutaneous region. "
07/01/2000 - "Twice weekly, for 38 weeks, topical application of NO-NTA at the concentration of 250 nmol to mice previously initiated with benzo(a)pyrene (BaP) caused 90% tumor incidence. "
07/01/2000 - "These results indicate that NO-NTA is a new tumor promoter and may induce tumor promotion by oxidant stress in CD-1 mouse skin."

07/01/2000 - "Application of the same amount of NO-NTA not only caused significant induction of hyperplasia but also epidermal ornithine decarboxylase (ODC) activity. "

07/01/2000 - "The NO-NTA-promoted tumors that were observed histologically in mice showed well-differentiated squamous cell carcinoma with invasion into the subcutaneous region. "