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alpha-conotoxin MII

inhibits alpha3beta2 nicotinic acetylcholine receptors; isolated from Conus magus; amino acid sequence in first source

Also Known As:

MII alpha-conotoxin

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Mollusk Venoms: 21
    - Conotoxins: 172
      - alpha-conotoxin MII: 6
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Mollusk Venoms: 21
      - Conotoxins: 172
        alpha-conotoxin MII: 6
  - Marine Toxins: 124
    - Mollusk Venoms: 21
      - Conotoxins: 172
        alpha-conotoxin MII: 6

Experts

1.	McIntosh, J Michael: 2 articles (06/2007 - 12/2004)
2.	Kasheverov, I E: 1 article (03/2012)
3.	Khiroug, L: 1 article (03/2012)
4.	Kriukova, E V: 1 article (03/2012)
5.	Salminen, O: 1 article (03/2012)
6.	Strukov, A S: 1 article (03/2012)
7.	Surin, A M: 1 article (03/2012)
8.	Talka, R: 1 article (03/2012)
9.	Tsetlin, V I: 1 article (03/2012)
10.	Tuominen, R: 1 article (03/2012)

Related Diseases

1.	Wounds and Injuries (Trauma) 01/01/2006 - "Wound repair was improved in the presence of nAChR agonists, nicotine, and acetylcholine, and delayed in the presence of alpha3beta2 neuronal nAChR antagonists, mecamylamine, alpha-conotoxin MII, and kappa-bungarotoxin; alpha-bungarotoxin, an antagonist of alpha7-nAChR, had no effect. "
2.	Alcoholism (Alcohol Abuse) 01/01/2004 - "Studies aimed at defining the nAChR subpopulation(s) involved in mediating ethanol-induced locomotor stimulation and accumbal dopamine overflow as well as ethanol-intake have revealed that alpha(3)beta(2) or alpha(6) (using alpha-Conotoxin MII) but not alpha(4)beta(2) (using dihydro-beta-erythroidine) or alpha(7) (using methyllycaconitine), could represent targets for developing new drugs in the treatment of alcoholism. "
3.	Ganglion Cysts (Ganglion) 07/01/2000 - "We report here that localized perfusion of the canine intracardiac ganglion in situ with an antagonist specific for nAChRs containing an alpha3/beta2 subunit interface (alpha-conotoxin MII 100-200 nm) resulted in reversible attenuation of the sinus cycle length (SCL) response by approximately 70% to electrical stimulation of the preganglionic vagus nerve. "
4.	Tobacco Use Disorder (Nicotine Dependence) 06/01/2007 - "This class of receptors, potentially important in nicotine addiction, binds alpha-conotoxin MII (alpha-CtxMII) with high affinity and is heterogeneous, consisting of several subtypes in mice, possibly an important consideration for the design of compounds that selectively activate or antagonize the alpha6 subclass of nAChRs. "
5.	Neuroblastoma 03/01/2012 - "[Effect of alpha-conotoxin MII and its N-terminal derivatives on Ca2+ and Na+ signals induced by nicotine in neuroblastoma cell line SH-SY5Y]."

Related Drugs and Biologics

1.	Nicotine
2.	Mecamylamine
3.	Bungarotoxins (alpha-Bungarotoxin)
4.	Acetylcholine (Acetylcholine Chloride)
5.	Dopamine (Intropin)
6.	Dihydro-beta-Erythroidine
7.	Ethanol (Ethyl Alcohol)
8.	methyllycaconitine
9.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)