ERRalpha estrogen-related receptor

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62 relevant articles (2 outcomes, 12 trials/studies) found for this Bio-Agent

Description: an orphan nuclear receptor

Also Known As:

ERR1 protein; ERRalpha; ERRalpha protein, human; ESRRA protein, human; Esrra protein, mouse; Esrra protein, rat; estrogen related receptor, alpha protein, mouse; estrogen related receptor, alpha protein, rat; estrogen-related receptor 1; estrogen-related receptor alpha; estrogen-related receptor alpha protein, human

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58433

Transcription Factors: 10777

Steroid Receptors: 1476

Estrogen Receptors: 1943

ERRalpha estrogen-related receptor: 62

Cytoplasmic and Nuclear Receptors: 553

Steroid Receptors: 1476

Estrogen Receptors: 1943

ERRalpha estrogen-related receptor: 62

Experts

1.	Teng, Christina: 1 article (03/2008)
2.	Archer, Trevor K: 1 article (03/2008)
3.	Hu, Peng: 1 article (03/2008)
4.	Martin, Jessica: 1 article (03/2008)
5.	Wang, Liangli: 1 article (03/2008)
6.	Kinyamu, H Karimi: 1 article (03/2008)
7.	Horie-Inoue, Kuniko: 1 article (06/2007)
8.	Takahashi, Satoru: 1 article (06/2007)
9.	Ogushi, Tetsuo: 1 article (06/2007)
10.	Inoue, Satoshi: 1 article (06/2007)

Related Diseases

1.	Carcinoma (Carcinomatosis) 06/15/2009 - "Our findings identify AIB1 as functionally relevant cofactor for ERRalpha in breast carcinoma. " 06/15/2009 - "Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma." 07/01/2004 - "Estrogen-related receptor alpha in human breast carcinoma as a potent prognostic factor." 11/01/2008 - "Introduction of a small interfering RNA directed to ERRalpha into the highly aggressive breast carcinoma MDA-MB-231 cell line dramatically reduced the migratory potential of these cells. " 07/01/2004 - "Results from our study suggest that ERRalpha possibly modulates the expression of ERE-containing estrogen-responsive genes, and ERRalpha immunoreactivity is a potent prognostic factor in human breast carcinoma." Order ALL the reference details at left...
2.	Neoplasms (Cancer) 06/15/2009 - "Accordingly, ERRalpha might be a rewarding target for treatment of endocrine-resistant tumors." 03/01/2009 - "These results suggest for the first time that inhibition of ERRalpha signaling via a subtype-specific antagonist may be an effective therapeutic strategy for ER-positive and ER-negative breast cancers." 01/01/2009 - "Immunohistochemical analysis of breast cancers revealed perinuclear and cytoplasmic localization of ERRalpha. " 06/01/2007 - "Univariate and multivariate hazard analyses revealed significant correlations between elevated ERRalpha expression and poor cancer-specific survival (p = 0.0141 and 0.0367, respectively). " 12/01/2006 - "Estrogen-related receptor alpha as a therapeutic target in cancer." Order ALL the reference details at left...
3.	Heart Failure 02/01/2009 - "Overall, our results implicate PGC-1alpha and ERRalpha in the pathophysiology of human heart failure, and define dynamic target gene sets sharing known interrelated regulatory mechanisms capable of contributing to the mitochondrial dysfunction characteristic of this disease process." 07/01/2007 - "These results demonstrate that the nuclear receptor ERRalpha is required for the adaptive bioenergetic response to hemodynamic stressors known to cause heart failure." 07/01/2007 - "ERRalpha(-/-) mice subjected to left ventricular (LV) pressure overload developed signatures of heart failure including chamber dilatation and reduced LV fractional shortening. " 07/01/2007 - "We hypothesized that the estrogen-related receptor alpha (ERRalpha), which recruits PGC-1alpha to metabolic target genes in heart, exerts protective effects in the context of stressors known to cause heart failure. " Order ALL the reference details at left...
4.	Endometrial Neoplasms (Endometrial Cancer) 05/01/2006 - "This study was to explore the regulatory effect of 17beta-estradiol (17beta-E(2)) on ERRalpha expression, and to elucidate the relationship between ERRalpha and ER signal pathway in endometrial carcinoma cell lines. " 01/01/2006 - "To discuss the role of ERRalpha in the endometrial carcinoma cells, this study was performed. " 08/01/2009 - "It is speculated that ERRalpha is a candidate for prognostic factors in uterine endometrial cancer, although ERRs are not directly related to growth of uterine endometrial cancer." 06/01/2007 - "Furthermore, cellular growth analysis showed that over-expression of ERRalpha induced cell growth increase of the ER negative endometrial cancer cells HEC-1A and HEC-1B (P < 0.05). " 06/01/2007 - "METHODS: Plasmid of pSG-ERRalpha was transfected into endometrial cancer cell lines HEC-1A, HEC-1B, and Ishikawa. " Order ALL the reference details at left...
5.	Breast Neoplasms (Breast Cancer) 08/01/2009 - "Taken together, the identification and functional characterization of the ERRalpha transcriptional network implicate ERRalpha signaling as a determinant of breast cancer heterogeneity." 08/01/2009 - "Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity." 03/01/2009 - "Furthermore, we report the differential expression of 83 genes involved in ERRalpha signaling in MCF-7 and BT-20 breast cancer cell lines. " 03/01/2009 - "This analysis led to the identification of a large number of potential ERRalpha target genes, many of which were subsequently validated in other breast cancer cell lines. " 03/01/2009 - "The specific aspects of ERRalpha function that are responsible for its actions in breast cancer, however, remain unclear. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	ERRalpha estrogen-related receptor
2.	Small Interfering RNA (siRNA)
3.	Messenger RNA (mRNA)
4.	Estrogens (Estrogen)
5.	Estrogen Receptor alpha
6.	Aromatase (CYP19)
7.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
8.	Proteins (Proteins, Gene)
9.	Hormones
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Mammaplasty (Breast Reconstruction)
3.	Ovariectomy (Oophorectomy)

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