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1192U90

structure given in first source

Also Known As:

2-amino-N-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)benzamide hydrochloride

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - 1192U90: 1
  - Piperazines: 26
    - 1192U90: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - 1192U90: 1

Related Diseases

1.	Schizophrenia (Dementia Praecox) 09/01/1996 - "The results suggest that 1192U90 would be effective for positive and negative symptoms of schizophrenia, with minimal liability for EPSs, and may also have anxiolytic properties." 09/01/1996 - "1192U90 was developed on the assumption that antagonism of 5-HT2 receptors efficacy yields more potently than D2 receptors against positive and negative symptoms of schizophrenia with minimal liability for extrapyramidal side effects (EPSs), and that 5-HT1A agonism further reduces EPSs and provides anxiolytic and antidepressant activity. "
2.	Catalepsy 09/01/1996 - "1192U90 was submitted to four tests that predict antipsychotic efficacy (antagonism of apomorphine-induced climbing in mouse, antagonism of apomorphine-induced circling in rats with unilateral 6-OHDA lesions, antagonism of amphetamine-induced hyperlocomotion in rat, and inhibition of conditioned avoidance in rat), two tests of 5-HT2 function (antagonism of 5-MeODMT-induced head twitches in mouse and antagonism of 5-HTP-induced wet dog shakes in rat), and three tests that predict EPS liability (antagonism of apomorphine-induced stereotypy in mouse and rat and induction of catalepsy in mouse). "

Related Drugs and Biologics

1.	Anti-Anxiety Agents (Anxiolytics)
2.	Antipsychotic Agents (Antipsychotics)
3.	Apomorphine
4.	Antidepressive Agents (Antidepressants)
5.	Amphetamine (Amfetamine)