a newly developed macrolide of the ascomycin type that interferes with early T-cell activation; structure given in first source
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relevant articles (2 outcomes,
Bio-Agent Context: Research Results
|1. ||Psoriasis (Pustulosis Palmaris et Plantaris)
- "To evaluate whether SDZ 281-240 exhibits antipsoriatic activity when applied topically, we tested 15 patients with severe, recalcitrant psoriasis, using a microplaque assay in randomized, double-blind, placebo-controlled study, comparing the therapeutic efficacy of the macrolide with a potent halogenated corticosteroid and vehicle.
- "Some psoriasis forms can be successfully treated with topical medicaments; serious and extensive forms cannot be cured without systemic treatment with retinoids (etretinate, acitretin, tazarotene) or with immunosuppressives (methotrexate, cyclosporine A, tacrolimus, SDZ 281-240).
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