|1.||Wang, Xiang-Yang: 11 articles (01/2014 - 06/2003)|
|2.||Subjeck, John R: 9 articles (01/2014 - 06/2003)|
|3.||Chen, Xing: 5 articles (06/2010 - 01/2004)|
|4.||Guo, Chunqing: 3 articles (01/2014 - 04/2013)|
|5.||Yu, Xiaofei: 3 articles (01/2014 - 04/2013)|
|6.||Fisher, Paul B: 3 articles (12/2013 - 05/2008)|
|7.||Sun, Xiaolei: 3 articles (06/2010 - 05/2008)|
|8.||Repasky, Elizabeth A: 3 articles (06/2010 - 06/2003)|
|9.||Yuan, Bangqing: 2 articles (10/2015 - 07/2012)|
|10.||Wang, Hongxia: 2 articles (01/2014 - 12/2013)|
08/01/2006 - "The continued secretion of grp170 dramatically reduced the tumorigenicity of B16 tumor cells in vivo, although the modification did not alter its transformation phenotype and cell growth rate. "
06/10/2003 - "In addition, tumor-derived grp170 elicited a potent cytotoxic T-lymphocyte response specific for B16F10 tumor, which correlates with in vivo protective effects. "
05/15/2008 - "Therefore, introducing immunostimulatory chaperone grp170 in situ strongly promotes the "immunogenic" cell death when delivered to the mda-7/IL-24-induced apoptotic tumor cells, indicating that an improved anticancer efficacy may be achieved by concurrently targeting both tumor and immune compartments. "
08/01/2009 - "In this study we demonstrate that genetic modification of weakly immunogenic murine prostate tumor cells (TRAMP-C2) by stable transfection with a secretable form of endoplasmic reticulum resident chaperone grp170 significantly enhances its immunogenicity in vivo. "
08/01/2006 - "In the present study, we determine the impact of extracellular targeting grp170 by molecular engineering on tumor immunogenicity and potential use of grp170-secreting tumor cells as a cancer vaccine. "
|2.||Melanoma (Melanoma, Malignant)
12/15/2013 - "Directing the clinically relevant, melanoma Ag gp100 to mouse-derived DCs by molecular adjuvant and chaperone Grp170 substantially facilitates Ag access to the ER. "
06/10/2003 - "In our study, we have evaluated the therapeutic efficacy of tumor-derived grp170 against the highly metastatic and poorly immunogenic murine melanoma B16F10. "
08/01/2006 - "Extracellular targeting of endoplasmic reticulum chaperone glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanoma."
|3.||Prostatic Neoplasms (Prostate Cancer)
08/31/2010 - "In conclusion, our findings supported the strategy of chaperone complex, based on PSCA and GRP170, could be an effective treatment for prostate cancer therapy."
08/01/2009 - "Given a repertoire of undefined antigens in prostate tumor, manipulation of cellular compartmentalization of immuno-stimulatory chaperone grp170 to elicit systemic tumor immunity may be used to improve treatment outcomes for prostate cancer when combined with other treatment modalities."
04/01/2015 - "The human BK PyV also relies on Grp170 for successful infection. "
08/01/2009 - "Furthermore, infection of C2 tumor cells with a nonreplicating adenoviral vectors encoding secretable grp170 promotes tumor immunogenicity more effectively than plasmid transduction, as shown by the increased production of pro-inflammatory cytokine TNF-alpha by dendritice cells and enhanced therapeutic efficacy in treating pre-established tumors. "
07/01/2012 - "In the present study, the natural chaperone complex between grp170 and the Pokemon was formed by heat shock, and its immunogenicity was detected by ELISPOT and (51)Cr-release assays in vitro and by tumor bearing models in vivo. "
01/01/2001 - "Last, we showed that mild, fever-like hyperthermic conditions enhance the vaccine efficiency of hsp110 as well as heat shock cognate 70, but not grp170. "
06/01/2010 - "Both hsp110 and grp170 readily formed complexes with antigenic peptides under physiologic conditions, and the peptide association could be further stimulated by heat shock. "
01/01/2004 - "This chapter focuses on the methodologies of these two vaccine strategies: I. purification of hsp110 and grp170 from tumor tissue or cell lines; II. generation and characterization of in vitro HSP-antigen complexes by heat shock using recombinant HSPs derived from a baculovirus protein expression system."
08/01/2007 - "Heat shock protein 110 (hsp110) and glucose-regulated protein (grp170) act as anti-cancer vaccines when complexed to tumor antigens by heat shock. "
|1.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|2.||Heat-Shock Proteins (Heat-Shock Protein)
|3.||HSP110 Heat-Shock Proteins
|5.||Neoplasm Antigens (Tumor Antigens)
|7.||glucose-regulated protein 170
|8.||Proteasome Endopeptidase Complex (Proteasome)
|9.||Molecular Chaperones (Chaperone, Molecular)
|2.||Transplantation (Transplant Recipients)