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IRL 2500

Endothelin-B receptor antagonist; structure in first source

Also Known As:

IRL-2500; N-(3,5-dimethylbenzoyl)-N-methyl-(4-phenylphenyl)alanyl-tryptophan

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        IRL 2500: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - IRL 2500: 3

Experts

1.	Fuka, Mayu: 2 articles (09/2015 - 01/2014)
2.	Koyama, Yutaka: 2 articles (09/2015 - 01/2014)
3.	Matsuyama, Emi: 2 articles (09/2015 - 01/2014)
4.	Michinaga, Shotaro: 2 articles (09/2015 - 01/2014)
5.	Nagase, Marina: 2 articles (09/2015 - 01/2014)
6.	Seno, Naoki: 2 articles (09/2015 - 01/2014)
7.	Yamamoto, Yui: 2 articles (09/2015 - 01/2014)
8.	Yamanaka, Daisuke: 2 articles (09/2015 - 01/2014)
9.	Goldstein, Sara R: 1 article (07/2018)
10.	Liu, Chen: 1 article (07/2018)

Related Diseases

1.	Cold Injury 01/01/2014 - "Induction of reactive astrocytes after cold injury was attenuated by ICV administration of BQ788 or IRL-2500. " 01/01/2014 - "Repeated administration of BQ788 and IRL-2500 beginning at 24 h after cold injury attenuated both the increase in brain water content and extravasation of markers. " 09/01/2015 - "Intracerebroventricular administration of BQ788 (10 μg) or IRL-2500 (10 μg) (selective ETB antagonists) attenuated brain edema and disruption of the blood-brain barrier after cold injury. " 09/01/2015 - "BQ788 and IRL-2500 reversed the cold injury-induced increases in MMP9 and VEGF-A expression. " 01/01/2014 - "Intracerebroventricular (ICV) administration of BQ788 (ETB antagonist), IRL-2500 (ETB antagonist), or FR139317 (ETA antagonist) prior to cold injury significantly attenuated the increase in brain water content. "
2.	Hemolysis 07/12/2018 - "We describe herein the design, synthesis, and biological evaluation of analogs of IRL 2500 that enhance the release of CO from COHb without hemolysis. "
3.	Brain Edema (Cerebral Edema) 09/01/2015 - "Intracerebroventricular administration of BQ788 (10 μg) or IRL-2500 (10 μg) (selective ETB antagonists) attenuated brain edema and disruption of the blood-brain barrier after cold injury. "

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