GPA 7

a guanosine triphosphate binding protein antagonist

Also Known As:

Arg-Pro-Lys-Pro-Gln-D-Trp-Phe-D-Trp-Met-NH2; GPA-7; GPA7; arginyl-prolyl-lysyl-prolyl-glutaminyl-tryptophyl-phenylalanyl-tryptophyl-methioninamide

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - GPA 7: 6

Experts

1.	Gao, Bin: 2 articles (01/2014 - 11/2013)
2.	Han, Huamin: 2 articles (01/2014 - 11/2013)
3.	He, Wen: 2 articles (01/2014 - 11/2013)
4.	Liu, Changzhen: 2 articles (01/2014 - 11/2013)
5.	Ma, Juan: 2 articles (01/2014 - 11/2013)
6.	Sun, Meiyi: 2 articles (01/2014 - 11/2013)
7.	Wang, Lei: 2 articles (01/2014 - 11/2013)
8.	Wang, Wei: 2 articles (01/2014 - 11/2013)
9.	Wang, Xiaomin: 2 articles (01/2014 - 11/2013)
10.	Zhang, Ganlin: 2 articles (01/2014 - 11/2013)

Related Diseases

1.	Sarcoidosis (Schaumann Disease) 11/01/2023 - "Seventy-four specimens were included: 25 with TAO, 6 with orbital GPA, 7 with orbital sarcoidosis, 24 with NSOI, and 12 healthy controls. " 01/01/2022 - "Eighty-three participants were included: 25 with TAO, 6 with orbital GPA, 7 with orbital sarcoidosis, 25 with NSOI and 20 healthy controls. "
2.	Melanoma (Melanoma, Malignant) 01/06/2014 - "A TCR-like chimeric receptor, specific for the melanoma-related gp100/HLA-A2 complex was created by joining a TCR-like antibody GPA7 with the endodomains of CD28 and CD3-ζ chain. " 11/01/2013 - "Collectively, these results demonstrate that the TCR-like Ab, GPA7, could redirect NK cells to target the intracellular antigen gp100 and enhance anti-melanoma activity, providing a promising immunotherapeutic strategy to prevent and treat melanoma. " 11/01/2013 - "The TCR-like antibody (Ab) GPA7 was selected against melanoma-associated gp100/human leukocyte antigen (HLA)-A2 complex and then fused to intracellular domain of CD3-ζ chain. "
3.	Microscopic Polyangiitis 07/01/2018 - "There were 25 patients of PRS (13 retrospective, 12 prospective), with following etiology : Granulomatosis with polyangiitis (GPA) 7, Microscopic polyangiitis (MPO) 4, Churg Strauss Syndrome (EGPA) 1, Goodpasture's syndrome 1, lupus 5, leptospirosis 5, dengue 2. All were given steroids, 18 (72%) were given pulse Cyclophosphamide (barring those with leptospirosis and dengue), ventilator support in 14 (56%) patients (8 invasive, 6 non-invasive), haemodialysis 3, plasmapheresis 1, Rituximab 2. Seventeen (68%) patients survived, mortality was high in those requiring invasive ventilator. "
4.	Anti-Glomerular Basement Membrane Disease (Goodpasture's Syndrome) 07/01/2018 - "There were 25 patients of PRS (13 retrospective, 12 prospective), with following etiology : Granulomatosis with polyangiitis (GPA) 7, Microscopic polyangiitis (MPO) 4, Churg Strauss Syndrome (EGPA) 1, Goodpasture's syndrome 1, lupus 5, leptospirosis 5, dengue 2. All were given steroids, 18 (72%) were given pulse Cyclophosphamide (barring those with leptospirosis and dengue), ventilator support in 14 (56%) patients (8 invasive, 6 non-invasive), haemodialysis 3, plasmapheresis 1, Rituximab 2. Seventeen (68%) patients survived, mortality was high in those requiring invasive ventilator. "
5.	Churg-Strauss Syndrome (Allergic Angiitis) 07/01/2018 - "There were 25 patients of PRS (13 retrospective, 12 prospective), with following etiology : Granulomatosis with polyangiitis (GPA) 7, Microscopic polyangiitis (MPO) 4, Churg Strauss Syndrome (EGPA) 1, Goodpasture's syndrome 1, lupus 5, leptospirosis 5, dengue 2. All were given steroids, 18 (72%) were given pulse Cyclophosphamide (barring those with leptospirosis and dengue), ventilator support in 14 (56%) patients (8 invasive, 6 non-invasive), haemodialysis 3, plasmapheresis 1, Rituximab 2. Seventeen (68%) patients survived, mortality was high in those requiring invasive ventilator. "

Related Drugs and Biologics

1.	Troleandomycin (TAO)
2.	Steroids
3.	HLA Antigens (Human Leukocyte Antigens)
4.	Cyclophosphamide (Cytoxan)
5.	Antigens
6.	Rituximab (Mabthera)

Related Therapies and Procedures

1.	Mechanical Ventilators (Ventilator)
2.	Plasmapheresis