persin

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3 relevant articles (0 outcomes, 1 trials/studies) found for this Bio-Agent

Description: isolated from the leaves of avocado (Persea americana); structure given in first source; RN given refers to compound with no isomeric designation

Also Known As:

(Z,Z)-1-acetyloxy-2-hydroxy-12,15-heneicosadien-4-one; 1-acetyloxy-2-hydroxy-12,15-heneicosadien-4-one; persin, R-(Z,Z)-isomer; persin, S-(Z,Z)-isomer

Bio-Agent Context: Research Results

Organic Chemicals: 40

Experts

1.	Sutherland, Robert L: 2 articles (10/2007 - 09/2006)
2.	Butt, Alison J: 2 articles (10/2007 - 09/2006)
3.	Roberts, Caroline G: 2 articles (10/2007 - 09/2006)
4.	Gurisik, Ebru: 1 article (10/2007)
5.	Biden, Trevor J: 1 article (10/2007)
6.	Seawright, Alan A: 1 article (09/2006)
7.	Macleod, John K: 1 article (09/2006)
8.	Liaw, Tracy Y E: 1 article (09/2006)
9.	Lehrbach, Gillian M: 1 article (09/2006)
10.	Kavallaris, Maria: 1 article (09/2006)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 09/01/2006 - "Further in vitro studies in a panel of human breast cancer cell lines show that persin selectively induces a G2-M cell cycle arrest and caspase-dependent apoptosis in sensitive cells" 10/01/2007 - "We have previously described a novel plant toxin, persin, derived from avocado leaves, which has unique in vivo actions in the mammary epithelium and Bim-dependent, cytotoxic effects in human breast cancer cells in vitro" 09/01/2006 - "A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells." 10/01/2007 - "Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism." 10/01/2007 - "These data show that persin should be further investigated as a potential novel cancer therapeutic agent because it significantly enhances the sensitivity of breast cancer cells to the cytotoxic effects of tamoxifen, regardless of their ER status, while displaying apparent specificity for the malignant phenotype." Get all the results and reference details, order at left...
2.	Neoplasms (Cancer) 09/01/2006 - "Due to the unique structure of the compound, persin could represent a novel class of microtubule-targeting agent with potential specificity for breast cancers." 10/01/2007 - "These data show that persin should be further investigated as a potential novel cancer therapeutic agent because it significantly enhances the sensitivity of breast cancer cells to the cytotoxic effects of tamoxifen, regardless of their ER status, while displaying apparent specificity for the malignant phenotype." Get all the results and reference details, order at left...
3.	Necrosis 09/01/2006 - "Persin was previously identified from avocado leaves as the toxic principle responsible for mammary gland-specific necrosis and apoptosis in lactating livestock" 01/01/1995 - "At doses of persin above 100 mg/kg necrosis of myocardial fibres may occur and hydrothorax may be present in severely affected animals" Get all the results and reference details, order at left...
4.	Hydrothorax 01/01/1995 - "At doses of persin above 100 mg/kg necrosis of myocardial fibres may occur and hydrothorax may be present in severely affected animals" Get all the results and reference details, order at left...
4 Diseases and 3 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Estrogen Receptor Modulators (Antiestrogen)
2.	Linoleic Acid (Linoleate)
3.	Tamoxifen
4.	Hormones
5.	Estrogens (Estrogen)
6.	4-hydroxytamoxifen
6 Drugs and Important Bio-Agents and 1 more articles analyzed in the Research Interface, order at left...

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