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zamifenacin
zamifenacin is the (R)-isomer; RN given for (+-)-isomer; structure in first source
Also Known As:
(3-diphenylmethoxy-1-(3,4)-methylenedioxyphenethyl)piperidine; zamifenacin, (R)-isomer
Networked:
2
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperidines: 17
zamifenacin: 2
Dioxoles
zamifenacin: 2
Related Diseases
1.
Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
06/01/1997 - "
In this multicentre, double-blind, parallel group, placebo-controlled study, the effect of a single dose of zamifenacin 10 mg or 40 mg on both fasting (30 min) and fed (60 min) colonic motor activity was assessed in 36 patients with irritable bowel syndrome (aged 25-68 years; 19 male).
"
06/01/1997 - "
A single 40 mg dose of zamifenacin significantly reduces colonic motility in irritable bowel syndrome patients without significant antimuscarinic effects.
"
06/01/1997 - "
Zamifenacin is a new potent gut M3 selective muscarinic antagonist developed for possible use in irritable bowel syndrome.
"
06/01/1997 - "
Zamifenacin (UK-76, 654) a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome.
"
2.
Infections
01/01/1999 - "
In the present study, we examined the antagonist binding profiles of 9 muscarinic antagonists (atropine, 4-DAMP, pirenzepine, oxybutynin, tiquizium, timepidium, propiverine, darifenacin and zamifenacin) for human muscarinic acetylcholine receptor subtypes (m1, m2, m3, m4 and m5) produced by using a baculovirus infection system in Sf9 insect cells, and rat tissue membrane preparations (heart and submandibular gland).
"
Related Drugs and Biologics
1.
Muscarinic Antagonists
2.
Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
3.
Pirenzepine
4.
Atropine
5.
darifenacin
6.
propiverine
7.
oxybutynin (Tavor)