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Org 9935

Also Known As:

4,5-dihydro-6-(5,6-dimethoxybenzo(beta)thiophene)-2-carboximidamide hydrochloride; Org-9935

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - Org 9935: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - Org 9935: 2

Experts

1.	Rohof, A: 1 article (10/2001)
2.	Santing, R E: 1 article (10/2001)
3.	Zaagsma, J: 1 article (10/2001)
4.	de Boer, J: 1 article (10/2001)
5.	van der Zee, N M: 1 article (10/2001)

Related Diseases

1.	Necrosis 05/01/1998 - "2. Tumour necrosis factor-alpha (TNF-alpha)-induced intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin expression were measured on HLMVEC monolayers at 6 h by a specific ELISA technique in the presence of different combinations of medium, rolipram, ORG 9935 and salbutamol. "
2.	Inflammation (Inflammations) 10/19/2001 - "In a guinea pig model of allergic asthma, we investigated the effects of the selective phosphodiesterase inhibitors rolipram (phosphodiesterase 4-selective), Org 9935 (phosphodiesterase 3-selective) and Org 20241 (dual phosphodiesterase 4/phosphodiesterase 3-selective), administered by aerosol inhalation in approximately equipotent bronchodilatory doses, on allergen-induced early and late asthmatic reactions, airway hyperreactivity and airway inflammation. "
3.	Asthma (Bronchial Asthma) 10/19/2001 - "In a guinea pig model of allergic asthma, we investigated the effects of the selective phosphodiesterase inhibitors rolipram (phosphodiesterase 4-selective), Org 9935 (phosphodiesterase 3-selective) and Org 20241 (dual phosphodiesterase 4/phosphodiesterase 3-selective), administered by aerosol inhalation in approximately equipotent bronchodilatory doses, on allergen-induced early and late asthmatic reactions, airway hyperreactivity and airway inflammation. "

Related Drugs and Biologics

1.	Rolipram
2.	Type 4 Cyclic Nucleotide Phosphodiesterases
3.	E-Selectin
4.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
5.	Cell Adhesion Molecules
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Phosphoric Diester Hydrolases (Phosphodiesterases)
8.	Phosphodiesterase Inhibitors
9.	Allergens
10.	Albuterol (Salbutamol)