N-palmitoylsphingosine

structure given in first source; RN given refers to (R*,S*-(E))-isomer

Also Known As:

C(16)-ceramide; C16-0(palmitoyl)ceramide; C16-ceramide; C16-palmitoylceramide; N-palmitoylsphingosine, (R*,S*-(E))-(+-); N-palmitoylsphingosine, R-(R*,S*-(E)); NFA(C16)CER; ceramide-C16; pCer cpd; palmitoylceramide

Networked: 26 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ogretmen, Besim: 5 articles (01/2018 - 10/2007)
2.	Garrett-Mayer, Elizabeth: 3 articles (01/2018 - 05/2015)
3.	Lu, Ping: 3 articles (01/2018 - 05/2015)
4.	Voelkel-Johnson, Christina: 3 articles (01/2018 - 05/2015)
5.	Bielawska, Alicja: 3 articles (05/2015 - 06/2008)
6.	Esmaeilniakooshkghazi, Amin: 2 articles (10/2018 - 01/2016)
7.	Fekry, Baharan: 2 articles (10/2018 - 01/2016)
8.	Krupenko, Natalia I: 2 articles (10/2018 - 01/2016)
9.	Krupenko, Sergey A: 2 articles (10/2018 - 01/2016)
10.	Szulc, Zdzislaw M: 2 articles (10/2018 - 09/2013)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 04/07/2023 - "Utilizing J20 mice, an Alzheimer disease mice model in which mice were injected after weaning with C16-ceramide, we found that these mice also show improved learning and short-term memory behavior when assessed by the Morris water maze test. "
2.	Insulin Resistance 02/20/2022 - "The present study indicates that C16-ceramide plays a pivotal role in inducing insulin resistance. " 02/20/2022 - "Insulin resistance induced by de novo pathway-generated C16-ceramide is associated with type 2 diabetes in an obese population." 11/24/2017 - "Using these 113 metabolites, combined with machine learning to segregate mice based on insulin sensitivity, we identified C22:1-CoA, C2-carnitine, and C16-ceramide as the best classifiers. "
3.	Colitis 11/14/2017 - "Adoptive transfer of CerS6-deficient splenocytes, which have significantly decreased levels of C16-ceramide, showed that CerS6-deficiency protected against the development of colitis. " 01/01/2018 - "In this study we used ceramide synthase 6 (CerS6) deficient mice, which have a reduced ability to generate long chain C16-ceramide, to investigate the role of this enzyme in dextran sodium salt (DSS)-induced colitis. "
4.	Neoplasms (Cancer) 12/01/2021 - "Furthermore, CerS6 promoted cell proliferation, colony formation and invasion by producing C16-ceramide and was required for tumor formation. " 10/08/2018 - "Here we report the mechanism for activation of p53 tumor suppressor by C16-ceramide. " 02/19/2015 - "Furthermore, pharmacological and genetic approaches established that modulation of CerS6 expression/activity in cancer cells altered the level of C16-ceramide, which in turn influenced plasma membrane fluidity and cell motility. " 01/01/2015 - "Stereospecific induction of apoptosis in tumor cells via endogenous C16-ceramide and distinct transcripts." 01/01/2016 - "Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in tumor biology. "
5.	Colonic Neoplasms (Colon Cancer) 07/01/2014 - "These data suggest a new role of EMD as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway in colon cancer cells. " 05/22/2015 - "Overexpression of CerS6 in HT29 colon cancer cells resulted in increased apoptotic susceptibility and preferential generation of C16-ceramide, which occurred at the expense of very long chain, saturated ceramides. " 06/01/2008 - "In both Molt-4 LXSN leukemia cells exposed to gamma-irradiation and in EB-1 colon cancer cells treated with ZnCl(2), p53 up-regulation led to de novo ceramide synthesis with predominance of N-palmitoylsphingosine (C16-ceramide) synthesis. "

Related Drugs and Biologics

1.	dihydroceramide desaturase
2.	Enzymes
3.	Sodium
4.	Salts
5.	Dextrans (Dextran)
6.	Ceramides
7.	Sphingolipids
8.	N-caproylsphingosine
9.	Histone Deacetylase 1
10.	Therapeutic Uses

Related Therapies and Procedures

1.	Therapeutics