Fenozan 50F

a di-fluorophenyl spirocyclopentane trioxane active against PLASMODIUM; structure given in first source

Also Known As:

fenozan B07; fenozan-50F; 4a,7a,-dihydro-6,7a-di(p-fluorophenyl)spiro(cyclopentane-1,3'-(7H)cyclopenta-1,2,4-trioxin)

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Malaria 04/01/1993 - "Fenozan-50F is considered to be a good candidate for eventual use as a therapeutic agent for infection with polyresistant malaria in man." 01/01/1997 - "Fenozan B07, a 1,2,4-trioxane endoperoxide with potent blood schizontocidal activity against drug-sensitive and drug-resistant rodent malaria parasites, exerted a modest potentiating action when administered with chloroquine (CQ) to mice infected with parasites of the CQ-resistant P. " 01/01/1997 - "Fenozan B07, a difluorinated 3,3'-spirocyclopentane, 1,2,4-trioxane, is a novel, second-generation antimalarial endoperoxide which is a potent blood schizontocide against strains of rodent malaria that are highly resistant to a wide spectrum of classical antimalarials. "
2.	Infections 04/01/1993 - "Fenozan-50F is considered to be a good candidate for eventual use as a therapeutic agent for infection with polyresistant malaria in man." 01/01/1997 - "In contrast to arteether, in a model using synchronous infection with Plasmodium vinckei petteri, Fenozan B07 inhibits the development of all asexual stages except preschizonts, as well as gametocytes. " 04/01/1993 - "berghei N infection in mice, Fenozan-50F is about half as active as arteether but nearly three times as active as sodium artesunate. "

1.	1,2,4-trioxane
2.	artemotil (arteether)
3.	Chloroquine (Aralen)
4.	Antimalarials (Antimalarial Agents)
5.	Artesunate