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FR 145237
an ACAT inhibitor; structure given in first source
Also Known As:
FR-145237; FR145237; N-benzyl-N-((3-(4-chlorophenyl)-5-methyl-2-benzofuranyl)methyl)-N'-(2,4,6-trifluorophenyl)urea
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzofurans: 26
FR 145237: 3
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Phenylurea Compounds: 1
FR 145237: 3
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenylurea Compounds: 1
FR 145237: 3
Related Diseases
1.
Hypercholesterolemia
01/01/1997 - "
To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced diabetic rats.
"
01/01/1997 - "
Effects of FR145237, an acyl-CoA:cholesterol acyltransferase inhibitor, on diet-induced hypercholesterolemia in diabetic rats.
"
12/07/1995 - "
These results suggest that FR145237 potently lowers the plasma cholesterol level in hypercholesterolemia induced by dietary cholesterol but not that by LDL receptor deficiency, and that FR145237 has a direct antiatherosclerotic activity on the arterial wall independent of its hypocholesterolemic activity.
"
2.
Atherosclerosis
12/07/1995 - "
Rabbits were fed a high-cholesterol diet for 8 weeks to establish aortic atherosclerosis and then fed a normal diet with or without FR145237 for 8 weeks.
"
12/07/1995 - "
Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits.
"
3.
Necrosis
10/01/1996 - "
In the normal rabbits, severe necrosis of the cells in the zona fasciculata and reticularis was observed 24 hr after intravenous injection of 3.2 mg/kg of FR145237, whereas no morphological changes could be found in the adrenal cells of the WHHL rabbits in spite of a higher plasma concentration of the drug.
"
Related Drugs and Biologics
1.
Streptozocin (Streptozotocin)
2.
LDL Receptors (LDL Receptor)
3.
Dietary Cholesterol
4.
Sterol O-Acyltransferase
5.
Cholesterol
Related Therapies and Procedures
1.
Intravenous Injections