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KL4 surfactant

a synthetic 21-amino acid peptide which mimics the hydrophobic and hydrophilic pattern of surfactant protein-B (SP-B)

Also Known As:

(Lys-Leu4)4-Lys; KL4-surfactant

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - KL4 surfactant: 8
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - KL4 surfactant: 8
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - KL4 surfactant: 8

Experts

1.	Christofidou-Solomidou, Melpo: 2 articles (11/2017 - 10/2006)
2.	Segal, Robert: 2 articles (11/2017 - 10/2006)
3.	Arguiri, Evguenia: 1 article (11/2017)
4.	Koumenis, Constantinos: 1 article (11/2017)
5.	Pietrofesa, Ralph A: 1 article (11/2017)
6.	Gregory, Timothy J: 1 article (05/2014)
7.	Henderson, Christopher: 1 article (05/2014)
8.	Lampland, Andrea L: 1 article (05/2014)
9.	Mammel, Mark C: 1 article (05/2014)
10.	Mazela, Jan: 1 article (05/2014)

Related Diseases

1.	Pneumonia (Pneumonitis) 11/01/2017 - "The results of this study showed that intranasal delivery of KL4 surfactant was able to preserve lung function as evidenced by adequate arterial oxygen saturation and reduced lung inflammation and oxidative stress; total white count and absolute neutrophil count was decreased in BALF, as were plasma pro-inflammatory cytokine levels and biomarker of oxidative stress. "
2.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/01/1996 - "The efficacy and safety of KL4-surfactant in preterm infants with respiratory distress syndrome." 08/01/1995 - "Positive end-expiratory pressure during KL4 surfactant instillation enhances intrapulmonary distribution in a simian model of respiratory distress syndrome." 01/01/1999 - "We therefore studied the magnitude and mechanisms of oxidative inactivation of a natural lung surfactant (NLS) and of two surfactants used for treatment of respiratory distress syndrome, beractant and KL4 surfactant (KL4). "
3.	Lung Injury 11/01/2017 - "KL4 surfactant is a promising MCM for mitigation of lung tissue damage after targeted, thoracic irradiation and has the potential to be developed as a broad-spectrum, multi-use MCM against chemical, biological, radiological or nuclear threat agents with potential to cause lung injury." 10/01/2006 - "KL4-surfactant prevents hyperoxic and LPS-induced lung injury in mice."
4.	Acute Lung Injury 05/01/2014 - "Aerosolized KL4 surfactant improves short-term survival and gas exchange in spontaneously breathing newborn pigs with hydrochloric acid-induced acute lung injury."
5.	Hyperoxia 08/01/2008 - "KL4-surfactant (Lucinactant) protects human airway epithelium from hyperoxia."

Related Drugs and Biologics

1.	Cytokines
2.	Biomarkers (Surrogate Marker)
3.	Surface-Active Agents (Surfactants)
4.	Hydrochloric Acid (Hydrogen Chloride)
5.	lucinactant
6.	beractant (Survanta)

Related Therapies and Procedures

1.	Positive-Pressure Respiration (Positive End-Expiratory Pressure)