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GK 128

a 5-hydroxytryptamine(3) receptor antagonist; structure given in first source

Also Known As:

2-((2-methylimidazol-1-yl)methyl)benzo(f)thiochromen-1-one monohydrochloride hemihydrate; GK-128

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - GK 128: 2
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        GK 128: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        GK 128: 2

Related Diseases

1.	Vomiting 10/04/1995 - "These data suggest that GK-128 has a potent inhibitory effect on emesis via the 5-HT3 receptor, and that the 5-HT3 receptor involved in emesis in Suncus murinus may be different from the classically defined 5-HT3 receptor in other animals such as rats, dogs and ferrets." 10/04/1995 - "GK-128 failed to inhibit copper sulfate-induced emesis. "
2.	Dehydration (Water Stress) 10/01/1996 - "The activation energy for dehydration, calculated by the Ozawa method using TG data, decreased with decreasing particle size and/or crystallinity of GK-128 crystals, e.g., the activation energies for dehydration of intact and jet-milled GK-128 were 128.1 and 75.9 kj/mol, respectively. " 10/01/1996 - "However, after pulverization by jet mill, the dehydration temperature of GK-128 was markedly lowered and the DSC endothermic peak due to dehydration disappeared. " 10/01/1996 - "Effect of pulverization on dehydration behavior of crystals of GK-128, a serotonin3 receptor antagonist."

Related Drugs and Biologics

1.	5-HT3 Serotonin Receptors (5 HT3 Receptor)
2.	Copper Sulfate (Sulfate, Copper)