10/04/1995 - "These data suggest that GK-128 has a potent inhibitory effect on emesis via the 5-HT3 receptor, and that the 5-HT3 receptor involved in emesis in Suncus murinus may be different from the classically defined 5-HT3 receptor in other animals such as rats, dogs and ferrets."
10/04/1995 - "GK-128 failed to inhibit copper sulfate-induced emesis. "
|2.||Dehydration (Water Stress)
10/01/1996 - "The activation energy for dehydration, calculated by the Ozawa method using TG data, decreased with decreasing particle size and/or crystallinity of GK-128 crystals, e.g., the activation energies for dehydration of intact and jet-milled GK-128 were 128.1 and 75.9 kj/mol, respectively. "
10/01/1996 - "However, after pulverization by jet mill, the dehydration temperature of GK-128 was markedly lowered and the DSC endothermic peak due to dehydration disappeared. "
10/01/1996 - "Effect of pulverization on dehydration behavior of crystals of GK-128, a serotonin3 receptor antagonist."
|1.||5-HT3 Serotonin Receptors (5 HT3 Receptor)
|2.||Copper Sulfate (Sulfate, Copper)