TA 993

structure given in first source; RN given refers to (cis-(-))- isomer

Also Known As:

3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one; TA 993, (cis-(+-)) maleate; TA 993, (cis-(-)) fumarate; TA 993, (cis-(-)) fumarate 1:1; TA-993

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Diltiazem: 2789
        TA 993: 4

Experts

1.	Doi, H: 2 articles (10/2001 - 05/2000)
2.	Karasawa, T: 1 article (10/2001)
3.	Katoh, M: 1 article (10/2001)
4.	Odawara, A: 1 article (10/2001)
5.	Inoue, H: 1 article (05/2000)
6.	Kaburaki, M: 1 article (05/2000)
7.	Narita, H: 1 article (05/2000)
8.	Suzumura, K: 1 article (05/2000)

Related Diseases

1.	Ischemia 05/01/2000 - "Protective effect of TA-993, a novel therapeutic agent for peripheral circulatory insufficiency, on skeletal muscle fatigue in a rat model of hindlimb ischemia."
2.	Fatigue 05/01/2000 - "Protective effect of TA-993, a novel therapeutic agent for peripheral circulatory insufficiency, on skeletal muscle fatigue in a rat model of hindlimb ischemia."
3.	Thrombosis (Thrombus) 03/01/1998 - "These results indicate that TA-993 has an antithrombotic effect on femoral arterial thrombosis and suggest that an increasing action on femoral blood flow of TA-993 is more relevant than its antiplatelet action to the antithrombotic effect in this model." 03/01/1998 - "We evaluated the antithrombotic effect of TA-993 in a canine model of femoral arterial thrombosis. " 03/01/1998 - "Antithrombotic action of TA-993, a new 1,5-benzothiazepine derivative, in a canine model of femoral arterial thrombosis." 04/01/1996 - "Orally administered TA-993 dose-dependently inhibited ADP-induced platelet aggregation ex vivo in dogs (0.3 to 10 mg/kg), significantly protected mice against collagen + epinephrine-induced thromboembolic death (10 mg/kg), and inhibited thrombus formation in an arteriovenous shunt in rats (30 mg/kg). "
4.	Hemolysis 10/15/2001 - "TA-993 and MB3 inhibited both the hypotonic hemolysis of human erythrocytes and the mechanical hemolysis of rat erythrocytes induced by turbulent flow. "

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Collagen
3.	Adenosine Diphosphate (ADP)
4.	1,5-benzothiazepine