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tubeimoside III

isolated from Bolbostemma paniculatum; structure given in first source
Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ma, R D: 1 article (05/2001)
2. Yu, L J: 1 article (05/2001)
3. Yu, T X: 1 article (05/2001)

Related Diseases

1. Neoplasms (Cancer)
12/01/1995 - "However, the important difference in bioactivities between tubeimosides I and III is the non-activity of tubeimoside III as an inhibitor of tumor promotion if administered orally. "
12/01/1995 - "Inhibition of the tumor promoting action of 12-O-tetradecanoylphorbol-13-acetate by tubeimoside III isolated from Bolbostemma paniculatum."
05/01/2001 - "The difference of chemical structure in B and/or C position between tubeimosides III and II plays an important role in enhancing biological activity and toxicity of tubeimoside III. Therefore tubeimosidre II may be the most promising agent for cancer chemoprevention and chemotherapy among tubeimosides I, II, and III."
05/01/2001 - "However, the anti-inflammatory, anti-tumor, and anti-tumorigenic activities of tubeimoside II are stronger than those of tubeimoside I, and the acute toxicity of tubeimoside II is lower than that of tubeimoside I; the anti-inflammatory, anti-tumor, and anti-tumorigenic activities of tubeimoside III are stronger than those of tubeimoside II, and the acute toxicity of tubeimoside III is also stronger than that of tubeimoside II. C-16 hydroxyl group of tubeimoside II plays an important role in enhancing biological activity of tubeimoside II and in decreasing its toxicity. "
12/01/1995 - "Tubeimoside III, the natural analog of tubeimoside I, also had an anti-inflammatory effect on mouse ear edema induced by arachidonic acid and TPA and a potent anti-tumor promoting effect on two-stage carcinogenesis of mouse skin after topical application. "
2. Carcinogenesis
3. Edema (Dropsy)

Related Drugs and Biologics

1. tubeimoside I
2. Hydroxyl Radical
3. Arachidonic Acid (Vitamin F)
4. tubeimoside II

Related Therapies and Procedures

1. Chemoprevention
2. Drug Therapy (Chemotherapy)