|1.||Folbergrová, Jaroslava: 2 articles (06/2009 - 04/2005)|
|2.||Haugvicová, Renata: 2 articles (06/2009 - 04/2005)|
|3.||Otáhal, Jakub: 2 articles (06/2009 - 04/2005)|
|4.||Druga, Rastislav: 2 articles (06/2009 - 04/2005)|
|5.||Chi, Zhao-Fu: 1 article (05/2011)|
|6.||Man, Xiao: 1 article (05/2011)|
|7.||Yao, Hong: 1 article (05/2011)|
|8.||Feng, Ya-Bo: 1 article (05/2011)|
|9.||Chi, Ling-Yi: 1 article (05/2011)|
|10.||Tsenov, Grygoriy: 1 article (06/2009)|
09/01/2004 - "We conclude, therefore, that 2R,4R-APDC itself impaired acquisition and consolidation, enhanced retrieval but in rats undergoing hypoxia, it improved acquisition, retrieval and when used at the dose of 100 nmol enhanced consolidation. "
09/01/2004 - "2R,4R-APDC had beneficial effect in hypoxia-induced memory impairment in passive avoidance test."
09/01/2004 - "In the elevated "plus" maze, rats pretreated with 2R,4R-APDC and then subjected to hypoxia shortened the time spent in open arms and prolonged the time spent in closed arms, reduced the time spent in open arms, i.e. "
09/01/2004 - "2R,4R-APDC effect on locomotor and exploratory activity was not changed after hypoxia, i.e. "
09/01/2004 - "2R,4R-APDC influence on hypoxia-induced impairment of learning and memory processes in passive avoidance test."
06/01/2009 - "The present findings clearly indicate that both anticonvulsant and neuroprotective effect of 2R,4R-APDC against DL-HCA-induced seizures is substantially diminished when the agonist is given after the onset of seizures as compared with its efficacy after the pretreatment (Exp. Neurol.192, 420-436, 2005)."
06/01/2009 - "The neuroprotective effect of 2R,4R-APDC was evaluated after 24 h and 6 days of survival following DL-HCA-induced seizures. "
06/01/2009 - "A tendency to lower number and a shorter duration of seizures was outlined in animals posttreated with 2R,4R-APDC, but the differences did not reach the level of statistical significance. "
04/01/2005 - "The neuroprotective effect of 2R,4R-APDC was evaluated after 24 h and 6 days of survival following DL-HCA-induced seizures. "
02/16/2001 - "2R,4R-APDC (0.1-1 micromol, i.c.v.) induced stimulus-independent, rapid and dose-dependent clonic seizures. "
|3.||Status Epilepticus (Complex Partial Status Epilepticus)
04/01/2004 - "Neuropharmacological study by intravenous injection of mGluR2/3 agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate [(2R,4R)-APDC] at different doses at 1h during pilocarpine induced status epilepticus showed that (2R,4R)-APDC could not stop seizures and neuronal death in the hilus of the dentate gyrus. "
02/16/2001 - "A reversal of the anticonvulsant activity of 2R,4R-APDC was observed at (>20 nmol) in each of the chemoconvulsant and sound-induced models of epileptic seizures. "
02/16/2001 - "The anticonvulsant activity of the selective group II metabotropic glutamate receptor (mGlu) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) has been evaluated in chemoconvulsant and sound-induced models of epileptic seizures in DBA/2 mice. "
03/23/1998 - "These findings suggest that the selective activation of the group II metabotropic glutamate receptors by agonists such as 2R,4R-APDC may be of therapeutic potential in the treatment of seizure disorders."
|1.||Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
|3.||metabotropic glutamate receptor 2
|6.||Dihydrotachysterol (AT 10)
|9.||metabotropic glutamate receptor type 1